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Nobel-Prize-winning structural biologist Dr. Venki Ramakrishnan will deliver an Academia Sinica Lecture entitled “My Adventures in the Ribosome”. The lecture, a part of the 2023 Academia Sinica Lecture Series, will take place on August 11, 2023 in the International Conference Hall (3F) of the Humanities and Social Sciences Building. General public and members of the media are welcome.
During the first half of 2023, major economies experienced the consequences of contractionary monetary policies to address inflation, resulting in a global economic slowdown and weakened demand. The ongoing inventory adjustment in the manufacturing sector negatively affected export orders and equipment investment in Taiwan. In the first quarter of 2023, the real GDP growth rate declined by 2.87%. Looking ahead, private consumption is expected to play a pivotal role in supporting economic growth in the second half of the year. External demand, however, remains constrained. As a result, we revise downward the projected real economic growth rate for 2023 to 1.56%.
Human use of fossil fuels results in ~36 billion tons of carbon dioxide being released annually, severely impacting the carbon balance on earth. A team led by Academia Sinica President James C. Liao and Professor Ming-Daw Tsai has discovered a new way to increase carbon fixation, the process by which CO2 is absorbed, by cyanobacteria (so called blue-green algae). The team’s findings, published in the journal Nature Metabolism in June 2023, provide a new opportunity to mitigate carbon imbalance in nature.
For over 250 years, biologists have been puzzled about why regenerative animals regrow lost appendages at a rate proportional to the degree of appendage loss. A team led by Dr. Chen-Hui Chen at the Institute of Cellular and Organismic Biology (ICOB) and Dr. Keng-Hui Lin at the Institute of Physics (IOP), Academia Sinica discovered a ‘mechanical wave’ that governs positional sensing during wound healing and regeneration. This study was published in Nature Physics in June 2023.
The 72nd Lindau Nobel Laureate Meeting will be held from 25–30 June 2023. Around 40 Nobel Laureates will be invited to meet 635 young (35 years of age or less) scientists from all over the world to engage in face-to-face discussions. Young scientists who had been selected for the 70th Lindau Nobel Laureate Meeting and took part in the digital meeting are invited to participate on site.
Department of International Affairs
2023/09/23
Special Lectures by the Vatican's Pontifical Academy of Sciences
Secretariat
2023/09/20
Academician Sun-Lin Chung Has Been Elected as an American Geophysical Union Fellow
Central Administrative Office
2023/08/22
Letter from President Liao: Policy to Supplement Stipends for Academia Sinica Ph.D. Students
Letter from President Liao to Ph.D. Students: Supplemental Stipends for Academia Sinica Ph.D. Students
Institute of Plant and Microbial Biology
2023/08/08
Dr. Chih-Horng Kuo Received the 2023 Derrick Edward Award from the International Organization for Mycoplasmology
2023/07/27
The Announcement of 2023 TIGP Admissions
2023/07/07
Nominations for the 34th Academicians Election will begin on July 17, 2023 (the deadline is October 17, 2023)
Nominations for Academia Sinica Honorary Academicians (2024) will begin on July 17, 2023 (the deadline is December 17, 2023). According to the regulations, Honorary Academicians must be nominated by at least 10 Academicians.
Division of Life Sciences-Institute of Molecular Biology
Dr. Jun-An Chen's Lab
Apply by：2023/09/30
Division of Life Sciences-Genomics Research Center
The Lee Lab 李志浩特聘研究員實驗室
The Lee Lab 李志浩特聘研究員實驗室 Postdoctoral Fellow 博士後研究
09/28
14:00 Institute of Atomic and Molecular Sciences
Live Cell Force Dynamics – Do Cell Membranes Support or Resist Tension Propagation?
10/02
10:00 Institute of Biomedical Sciences
Neuron-glial interactions in health and disease: from cognition to cancer
10:00 Institute of History and Philology
The Tags of Grave Goods from the Warring States Period to the Western Han Dynasty and Related Issues
11:00 Agricultural Biotechnology Research Center
What animal self-medication in the wild can teach us about antiparasitic and other phytotherapies for humans and domestic animals?
11:00 Institute of Cellular and Organismic Biology
Gene Regulation by 3D Genome Topology in Single Cells
14:00 Institute of History and Philology
[Online Book Talk] "Sacred Rivals: Catholic Missions and the Making of Islam in Nineteenth-Century France and Algeria"
10/03
10:00 Institute of Cellular and Organismic Biology
True multiomic spatial analysis for biological research
11:00 Institute of Biomedical Sciences
Imaging functional networks in the rodent brain
13:00 Institute of Physics
Scattering-based optical interference microscopy for unveiling nanostructure dynamics in complex systems
10/04
10:00 Genomics Research Center
From Cells to Systems-- understanding how cells collectively perform systems - level functions in health and disease from a single cell multiomic perspective
14:00 Institute of Astronomy and Astrophysics
Hot Jupiters and Super-Earths: Spin-Orbit Dynamics in Exoplanetary Systems
14:00 Institute of European and American Studies
The Chinese Question: The Gold Rushes and Global Politics
The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. This process requires the involvement of nuclear transport receptors, collectively termed karyopherin- (Kap-) in yeast, and various regulatory factors. Previous studies showed that Kap114p, a Kap- that mediates nuclear import of yeast TBP (yTBP), modulates yTBP-dependent transcription. However, how Kap114p associates with yTBP to exert its multifaceted functions has remained elusive. The team led by Dr. Kuo-Chiang Hsia (Institute of Molecular Biology, Academia Sinica) and Dr. Wei-Yi Chen (Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University) presents a cryo-EM structure of Kap114p, one of the Kap-βs, in complex with TATA box binding protein and reveals a non-canonical function beyond nuclear transport that modulates TBP-dependent transcription. This study has been published in in the journal Nature Communications.
A research team led by Dr. Yi-Ping Hsueh, Distinguished Research Fellow at the Institute of Molecular Biology, Academia Sinca used high-end optical microscopy and biochemical approaches to demonstrate that KLHL17 and SYNPO, two autism-linked proteins, act in concert to regulate the organization and distribution of the spine apparatus, a specialized endoplasmic reticulum structure at excitatory synapses. KLHL17 and SYNPO promote clustering of the spine apparatus in the excitatory synapse to regulate calcium dynamics and consequently influence neuronal plasticity and activation. Furthermore, via collaboration with Dr. Bi-Chang Chen, Associate Research Fellow at the Research Center of Applied Sciences, they applied an improved expansion microscopy technology to successfully observe the three-dimensional ultrastructure and organization of the spine apparatus, as well as of the KLHL17 and SYNPO proteins, with an ultra-resolution of nearly 30 nanometers. Their research clearly links the function of the spine apparatus to ASD via control of synaptic plasticity. This study has been published in the journal PLOS Biology (August 2023).
A study has unraveled a mystery that persisted for fifty years in plant science – the elusive role of Pathogenesis-Related Protein 1 (PR1) in plant immunity. Led by Dr. Yet-Ran Chen at the Agricultural Biotechnology Research Center, Academia Sinica, this research casts a revealing light on the pivotal mechanism governing the enzymatic transformation of canonical immune biomarker PR1 into a potent CAPE cytokine. This transformation initiates plant systemic acquired resistance (SAR), a critical defense function against pathogenic infection. Remarkably, even plants incapable of synthesizing or perceiving salicylic acid, a central hormone for activating SAR, can activate systemic immunity when exposed to trace amounts of CAPE. This achievement serves as a foundation for enhancing crops' resilience against diseases and introduces novel perspectives for mitigating the adverse effects of global warming on plant immunity. This study has been published in the journal Nature Communications (August 2023).
Unlocking the potential of protein activation has historically posed challenges, necessitating extensive screening and biochemical assays. Dr. Kuen-Phon Wu at the Institute of Biological Chemistry has led a team to demonstrate a paradigm shift. By integrating the advanced deep learning tool, ProteinMPNN, they have engineered ubiquitin into a potent allosteric activator tailored for Rsp5 E3 ligase. The entire process was fully automated from protein designs to sample preparation to functional assays took only three months. This milestone heralds a new era, where AI-driven protein design obviates the need for exhaustive experimental screening and validation. This study has been published in in the journal ACS Synthetic Biology (August 2023).
The latest issue of Asia-Pacific Research Forum has just been published by the Center for Asia-Pacific Area Studies (CAPAS), RCHSS. Articles in this issue (No. 72) include:
Twenty-nine scholars author this book to review the development of political science in Taiwan.
We are proud to announce the publication of Grammatical Studies on Early Chinese Dialects (早期漢語方言語法), edited by Dr. Min-hua Chiang, Research Fellow of ILAS and Dr. Carine Yuk-man Yiu, Associate Professor from The Hong Kong University of Science and Technology.
We are pleased to announce the new publication of issue 24.3 of Language and Linguistics. This issue includes 5 articles:
Please see the table of contents below:
The newest issue of the Journal of Social Sciences and Philosophy has just been published by the Research Center for Humanities and Social Sciences. Articles in this issue (Vol.35, No.2) include:
Using well-preserved fossil fish otoliths from the Solomon Sea in the southwest edge of equatorial Pacific Ocean, Dr. Chien-Hsiang Lin’s research team reconstructed deep-sea fish communities over the past 460,000 years. Combining ancient seawater temperature records with fish diversity and abundance, they discovered a close relationship between tropical deep-sea fish communities and fluctuating seawater temperatures. These insights shed light on the intricate dynamics of fish structures in response to temperature changes. This study has been published in in the journal Science Advances in July 2023
The "IceCube" Neutrino Observatory, consisting of over 350 scientists worldwide, has made a breakthrough in astronomy by generating an image of the Milky Way galaxy using high-energy neutrinos for the first time. This confirms the long-standing speculation about the Milky Way being a source of high-energy neutrinos. Accumulating ten years of data on over 60,000 neutrinos, scientists rely on models and machine learning.
Algorithmic bias is an emerging challenge in law enforcement. Dr. Tzu-Wei Hung, Associate Research Fellow from the Institute of European and American Studies, Academia Sinica and Dr. Chun-Ping Yen, assistant professor from Soochow University, form spearhead efforts to analyze racial discrimination in Chicago’s predictive policing with the contrastive causation model.
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