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The Wang lab at the Genomics Research Center (GRC), Academia Sinica in Taipei, is seeking highly motivated and creative researchers to join our team. Our lab focuses on energy metabolism, adipocyte biology, and mitochondrial function, with an emphasis on their roles in metabolic diseases such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).
We utilize CRISPR-based functional genomics, small-molecule screening, and mitochondrial biology to uncover novel regulators of brown and beige fat thermogenesis, adipose tissue plasticity, and metabolic homeostasis. Our goal is to develop innovative therapeutic strategies for metabolic disorders.
- Key Research Areas -
* Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. (Nat Commun 2024)
* Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. (Nat Metab. 2022)
* CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. (Sci Transl Med. 2020)
* Thermogenic adipocyte biology and metabolic regulation (Nat Rev Endocrinol, 2021)
If you are enthusiastic about metabolism research and aspire to work in an interdisciplinary and collaborative environment, we invite you to apply!

The Wang lab at the Genomics Research Center (GRC), Academia Sinica in Taipei, is seeking highly motivated and creative researchers to join our team. Our lab focuses on energy metabolism, adipocyte biology, and mitochondrial function, with an emphasis on their roles in metabolic diseases such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD).
We utilize CRISPR-based functional genomics, small-molecule screening, and mitochondrial biology to uncover novel regulators of brown and beige fat thermogenesis, adipose tissue plasticity, and metabolic homeostasis. Our goal is to develop innovative therapeutic strategies for metabolic disorders.
- Key Research Areas -
* Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. (Nat Commun 2024)
* Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. (Nat Metab. 2022)
* CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. (Sci Transl Med. 2020)
* Thermogenic adipocyte biology and metabolic regulation (Nat Rev Endocrinol, 2021)
If you are enthusiastic about metabolism research and aspire to work in an interdisciplinary and collaborative environment, we invite you to apply!

The position involves assisting the Center’s faculty members with their research by conducting data mining, knowledge extraction, and data analysis. Specific responsibilities include:
1. Analyzing the content, dissemination, and evolution of online public opinion.
2. Applying big data analytics and artificial intelligence methods in social science research.
3. Developing computational systems to enhance the sharing of knowledge and its social impact.

針對臺灣地區一般民眾，執行臺灣人體生物資料庫計畫大台中地區宣導及收案作業。
工作內容包括：計畫宣導、問卷訪談、身體檢測、抽血與檢體處理等。

針對臺灣地區一般民眾，執行臺灣人體生物資料庫計畫大台北地區宣導及收案作業。
工作內容包括：計畫宣導、問卷訪談、身體檢測、抽血與檢體處理等。

1. 執行metagenomics、NGS次世代序列或RNA-sequencing等結果處理及資料分析、統整
2. 執行程式撰寫及相關大數據分析
3. 協助實驗室網頁及相關網路資訊系統管理
4. 協助研究結果彙整與成果報告撰寫
5. 與跨領域學門/實驗室合作，整合及共同分析實驗數據

The lab is using moss (Physcomitrium patens) as a model to
investigate various developmental biology-related questions
in plants. The lab routinely employs techniques such as
genetic manipulations, protein expression/purification, and
confocal microscopy observation. We encourage those
interested in plant biology to be part of the team.
實驗室網站：https://sites.google.com/view/kock-lab/home

本實驗室的研究重點為傳染病及癌症新藥研發，利用結構生物學的技術（X光結晶學，低溫電子顯微鏡）探討新冠肺炎，流感，抗藥性細菌感染以及癌細胞之膜蛋白及醣蛋白結構，作為新藥研發的基礎。
1.藉由分析蛋白質的立體空間結構，作為新藥設計的基礎。
2.運用細胞及動物實驗模型，探討新型藥物之廣度及效能。
My lab foucuses on structural biology and drug discovery in infectious diseases and cancers. X-ray crystallography and cryo-EM are being used to study membrane proteins and glycoproteins in SARS-COV-2, influenza viruses, drug-resistant bacteria and cancers, to provide structural basis for drug-discovery and vaccine design. In vitro cell based assays and in vivo animal models are being used to validate the efficacy of novel vaccines.

【工作內容 / Responsibilities】
本實驗室的研究重點為傳染病及癌症新藥研發，利用結構生物學的技術（X光結晶學，低溫電子顯微鏡）探討新冠肺炎，流感，抗藥性細菌感染以及癌細胞之膜蛋白及醣蛋白結構，作為新藥研發的基礎。
1.藉由分析蛋白質的立體空間結構，作為新藥設計的基礎。
2.運用細胞及動物實驗模型，探討新型藥物之廣度及效能。
My lab foucuses on structural biology and drug discovery in infectious diseases and cancers. X-ray crystallography and cryo-EM are being used to study membrane proteins and glycoproteins in SARS-COV-2, influenza viruses, drug-resistant bacteria and cancers, to provide structural basis for drug-discovery and vaccine design. In vitro cell based assays and in vivo animal models are being used to validate the efficacy of novel vaccines.

中央研究院環境變遷研究中心「空氣品質專題中心」誠徵專任研究人員1名，職級可為助研究員、副研究員或研究員（相當於大學助理教授、副教授、教授）。該職位最早可於2026年1月1日起聘。

The "Air Quality Research Center" of the Research Center for Environmental Changes, Academia Sinica, is seeking to recruit one full-time tenure track researcher at the rank of Assistant Research Fellow, Associate Research Fellow, or Research Fellow (equivalent to Assistant Professor, Associate Professor, or Professor in universities). This position starts as early as January 1, 2026.

Two potential research areas are:

1. Giant viruses: evolution of viral gigantism, genome regulation, and virus-host interactions

Giant viruses are DNA viruses with extraordinary genomes that are associated with a wide range of eukaryotic hosts, including animals, fungi, amoebae, algae, and many other microeukaryotes.


2. Phages: evolution of phage resistance and susceptibility and dynamic phage-bacteria interactions

We focus on phages that infect antibiotic-resistant bacteria to study what determines the outcome of phage infection and to apply this knowledge to develop broad-range phages.

Responsibility: (either)
(1) Exploring epigenetic control in shaping sexual dimorphic circuit.
(2) Exploring the neural circuit mechanisms through Drosophila olfactory virtual reality system
(3) Exploring circuit integration of thermo-, hygro-, and olfactory sensation.