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The major research interests in the LAI lab are to understand the molecular mechanisms underlying how bacterial pathogens deploy protein secretion systems for survival at its ecological niche and successful infection inside the plant host. We study the mechanistic and biological insights of the two major protein secretion nanomachines, type IV and type VI secretion systems (T4SS and T6SS), in Agrobacterium tumefaciens, the causal agent of crown gall disease and powerful gene transfer tool. We also aim to identify novel agrobacterial and plant genes critical for plant transformation and gene editing. The knowledge may provide new insights to improve Agrobacterium-mediated plant transformation and translational applications in biomedicine and/or agriculture.

The postdoc will carry out a two-year research grant to study the antibacterial T6SS with focuses to investigate the T6SS evolution and assembly mechanisms.

The LAI lab provides the research environments and expertise on studies of protein secretion and pathogen-plant interactions using various tools including genetics/genomics, molecular biology, biochemistry/proteomics, and cell biology. The research may expand to study structural aspects of T6SS-assocaited protein complex using X-ray crystallography and cryoEM. The postdoc is also encouraged to develop an independent project and will be trained to serve as a mentor toward an independent investigator. The LAI lab is also active in international collaborations, which will bring opportunities for abroad training.

The major research interests in the LAI lab are to understand the molecular mechanisms underlying how bacterial pathogens deploy protein secretion systems for survival at its ecological niche and successful infection inside the plant host. We study the mechanistic and biological insights of the two major protein secretion nanomachines, type IV and type VI secretion systems (T4SS and T6SS), in Agrobacterium tumefaciens, the causal agent of crown gall disease and powerful gene transfer tool. We also aim to identify novel agrobacterial and plant genes critical for plant transformation and gene editing. The knowledge may provide new insights to improve Agrobacterium-mediated plant transformation and translational applications in biomedicine and/or agriculture.

The Research Assistant will work with a senior Ph.D. student or a postdoc to carry out a two-year research grant to study the antibacterial T6SS with focuses to investigate the T6SS evolution and assembly mechanisms.

The LAI lab provides the research environments and expertise on studies of protein secretion and pathogen-plant interactions using various tools including genetics/genomics, molecular biology, biochemistry/proteomics, and cell biology. The research may expand to study structural aspects of T6SS-assocaited protein complex using X-ray crystallography and cryoEM. The postdoc is also encouraged to develop an independent project and will be trained to serve as a mentor toward an independent investigator. The LAI lab is also active in international collaborations, which will bring opportunities for abroad training.

We are looking for a post-doc for a project to examine evolution and speciation in Caenorhabditis nematodes using molecular and genetic approaches.
我們欲招募一名博士後研究，參與一項利用分子和遺傳學方法研究Caenorhabditis 屬線蟲演化與物種形成的計畫。

Postdoctoral Researcher in Family Change and Low Fertility in East Asia
The Institute of Sociology, Academia Sinica invites applications for a postdoctoral researcher to join a research program on family change, partnership formation, and low fertility in Taiwan and East Asia over a 2-year period (with renewal possibility). The position offers opportunities to develop independent publications within the broad themes of the project. The position involves no teaching load and also provides mentorship toward publication in leading journals. The position is particularly suitable for early-career researchers seeking to establish an independent publication record in family demography and population studies.

The research program seeks to understand how contemporary demographic change—including delayed partnership formation, rising singlehood, marriage, cohabitation, changing gender relations, persistent low fertility, birth outcomes, and social inequalities—is reshaping family life in Taiwan and East Asia. Through nationally representative survey data and comparative research, we aim to contribute to broader theoretical debates on family change, inequality, and demographic transformation.

Research themes
•singlehood and unpartnered adults;
•partnership formation and marriage;
•fertility intentions;
•gender, values, and family change;
•inequality in low-fertility societies;
•Taiwan and comparative East Asian demography.

Responsibilities
•develop independent and collaborative research papers;
•analyze survey and/or register-based demographic data;
•contribute to international journal manuscripts;
•participate in workshops, conferences, and cross-country research meetings;
•help strengthen the broader research program.

Academia Sinica, Taiwan, invites applications and nominations for the position of Director of the Institute of Cellular and Organismic Biology (ICOB). The initial appointment is for a period of three years (renewable for a second term), and will also carry the title of Research Fellow.

As the pre-eminent academic research institution in Taiwan, Academia Sinica is devoted to basic and applied research in life sciences, mathematics and physical sciences, humanities, and social sciences. ICOB currently consists of 22 laboratories, several of which are located at the Marine Research Station in Yilan County. ICOB conducts research in the following four focal areas: “Cellular Dysfunction”, “Eco-Evo-Devo”, “Neuroscience”, and “Stem Cell and Regenerative Biology”. ICOB is well funded and equipped with modern research facilities managed by experienced research specialists. ICOB maintains a high research standard with a high-quality publication record. For more detailed information about Academia Sinica and ICOB, please see http://www.sinica.edu.tw and https://icob.sinica.edu.tw/Eng, respectively.

針對臺灣地區一般民眾，執行臺灣人體生物資料庫計畫大台北地區宣導及收案作業。
工作內容包括：計畫宣導、問卷訪談、身體檢測、抽血與檢體處理等。

- Assist in studies of neuronal development,
synaptic plasticity, and mechanisms underlying
learning, memory, or sensory functions.
- Depending on expertise and interest, tasks may
include: cell biology, basic biochemistry, imaging,
data analysis, electrophysiology, or mouse
behavioral experiments.
- Support general laboratory operations and
management.

B細胞的發育分化與恆定，及其與疾病關聯性之研究。
使用人類檢體，基因剔除或轉殖小鼠動物模式實驗來研究B細胞功能，及於生理恆定與疾病進程所扮演之角色與分子機制。

Research and Work Content
• Research Focus: Research on B cell development, differentiation, and homeostasis, and their relationship with diseases.
• Job Description: Using human specimens , knockout or transgenic mouse models to study B cell function and the molecular mechanisms they play in physiological homeostasis and disease progression.

Molecular Mechanisms of Genome Stability
The Liang Laboratory at the Institute of Biological Chemistry, Academia Sinica, investigates the molecular mechanisms that preserve genome integrity during DNA replication and DNA repair. We combine structural biology, biochemistry, cell biology and functional genomics using state-of-the-art experimental approaches to understand how cells respond to replication stress, repair damaged DNA and maintain chromosome integrity. Our goal is to uncover fundamental mechanisms of genome maintenance while identifying new therapeutic opportunities for cancer.
Current research areas include:
• Break-induced replication (BIR)
• Holliday junction processing
• DNA replication stress
• Alternative lengthening of telomeres (ALT)
Why Join the Liang Laboratory?
Members of the Liang Laboratory will have the opportunity to:
• investigate fundamental questions in genome stability with broad implications for human health and disease
• develop expertise across structural biology, biochemistry, molecular biology, cell biology and functional genomics
• receive close scientific mentorship while developing independence and leading their own research projects
• collaborate with leading researchers in Taiwan and internationally
• present their work at international conferences and publish in leading international journals
We are committed to fostering an open, collaborative and supportive research environment where members are encouraged to think critically, develop their own ideas and grow into independent scientists.

Academia Sinica, Taiwan, invites applications and nominations for the position of Director of the Institute of Molecular Biology (IMB). The initial appointment is for a period of three years and is renewable for a second term; if necessary for reasons of academic development and upon approval by the President of Academia Sinica, the Director may serve a third term. The position carries the title of Research Fellow or Distinguished Research Fellow (equivalent to Professor or Distinguished Professor).

As the pre-eminent academic institution in Taiwan, Academia Sinica is devoted to basic and applied research in mathematics and physical sciences, life sciences, and humanities and social sciences. IMB, comprising 30 faculty members, conducts fundamental research to advance the understanding of biological processes at the molecular, cellular, and organismal levels. Research at IMB spans diverse and interconnected areas of contemporary biology, integrating molecular, structural, imaging, and systems approaches to investigate complex biological questions. IMB is well funded and equipped with modern research facilities. It maintains a high research standard with an excellent publication record. For details about Academia Sinica and IMB, please consult the websites below:
http://www.sinica.edu.tw
https://www.imb.sinica.edu.tw/en/

Molecular Mechanisms of Genome Stability

The Liang Laboratory at the Institute of Biological Chemistry, Academia Sinica, investigates the molecular mechanisms that preserve genome integrity during DNA replication and DNA repair. We combine structural biology, biochemistry, cell biology and functional genomics using state-of-the-art experimental approaches to understand how cells respond to replication stress, repair damaged DNA and maintain chromosome integrity. Our goal is to uncover fundamental mechanisms of genome maintenance while identifying new therapeutic opportunities for cancer.
Current research areas include:
• Break-induced replication (BIR)
• Holliday junction processing
• DNA replication stress
• Alternative lengthening of telomeres (ALT)

Why Join the Liang Laboratory?

Members of the Liang Laboratory will have the opportunity to:
• investigate fundamental questions in genome stability with broad implications for human health and disease
• develop expertise across structural biology, biochemistry, molecular biology, cell biology and functional genomics
• receive close scientific mentorship while developing independence and leading their own research projects
• collaborate with leading researchers in Taiwan and internationally
• present their work at international conferences and publish in leading international journals
We are committed to fostering an open, collaborative and supportive research environment where members are encouraged to think critically, develop their own ideas and grow into independent scientists.

1.協助學術研究工作，包括撰寫程式、文書處理、參加讀書會、蒐集資料等。
2.兼辦相關行政業務。