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Molecular Mechanisms of Genome Stability

The Liang Laboratory at the Institute of Biological Chemistry, Academia Sinica, investigates the molecular mechanisms that preserve genome integrity during DNA replication and DNA repair. We combine structural biology, biochemistry, cell biology and functional genomics using state-of-the-art experimental approaches to understand how cells respond to replication stress, repair damaged DNA and maintain chromosome integrity. Our goal is to uncover fundamental mechanisms of genome maintenance while identifying new therapeutic opportunities for cancer.
Current research areas include:
• Break-induced replication (BIR)
• Holliday junction processing
• DNA replication stress
• Alternative lengthening of telomeres (ALT)

Why Join the Liang Laboratory?

Members of the Liang Laboratory will have the opportunity to:
• investigate fundamental questions in genome stability with broad implications for human health and disease
• develop expertise across structural biology, biochemistry, molecular biology, cell biology and functional genomics
• receive close scientific mentorship while developing independence and leading their own research projects
• collaborate with leading researchers in Taiwan and internationally
• present their work at international conferences and publish in leading international journals
We are committed to fostering an open, collaborative and supportive research environment where members are encouraged to think critically, develop their own ideas and grow into independent scientists.

Academia Sinica, Taiwan, invites applications and nominations for the position of Director of the Institute of Molecular Biology (IMB). The initial appointment is for a period of three years and is renewable for a second term; if necessary for reasons of academic development and upon approval by the President of Academia Sinica, the Director may serve a third term. The position carries the title of Research Fellow or Distinguished Research Fellow (equivalent to Professor or Distinguished Professor).

As the pre-eminent academic institution in Taiwan, Academia Sinica is devoted to basic and applied research in mathematics and physical sciences, life sciences, and humanities and social sciences. IMB, comprising 30 faculty members, conducts fundamental research to advance the understanding of biological processes at the molecular, cellular, and organismal levels. Research at IMB spans diverse and interconnected areas of contemporary biology, integrating molecular, structural, imaging, and systems approaches to investigate complex biological questions. IMB is well funded and equipped with modern research facilities. It maintains a high research standard with an excellent publication record. For details about Academia Sinica and IMB, please consult the websites below:
http://www.sinica.edu.tw
https://www.imb.sinica.edu.tw/en/

Molecular Mechanisms of Genome Stability
The Liang Laboratory at the Institute of Biological Chemistry, Academia Sinica, investigates the molecular mechanisms that preserve genome integrity during DNA replication and DNA repair. We combine structural biology, biochemistry, cell biology and functional genomics using state-of-the-art experimental approaches to understand how cells respond to replication stress, repair damaged DNA and maintain chromosome integrity. Our goal is to uncover fundamental mechanisms of genome maintenance while identifying new therapeutic opportunities for cancer.
Current research areas include:
• Break-induced replication (BIR)
• Holliday junction processing
• DNA replication stress
• Alternative lengthening of telomeres (ALT)
Why Join the Liang Laboratory?
Members of the Liang Laboratory will have the opportunity to:
• investigate fundamental questions in genome stability with broad implications for human health and disease
• develop expertise across structural biology, biochemistry, molecular biology, cell biology and functional genomics
• receive close scientific mentorship while developing independence and leading their own research projects
• collaborate with leading researchers in Taiwan and internationally
• present their work at international conferences and publish in leading international journals
We are committed to fostering an open, collaborative and supportive research environment where members are encouraged to think critically, develop their own ideas and grow into independent scientists.

B細胞的發育分化與恆定，及其與疾病關聯性之研究。
使用人類檢體，基因剔除或轉殖小鼠動物模式實驗來研究B細胞功能，及於生理恆定與疾病進程所扮演之角色與分子機制。

Research and Work Content
• Research Focus: Research on B cell development, differentiation, and homeostasis, and their relationship with diseases.
• Job Description: Using human specimens , knockout or transgenic mouse models to study B cell function and the molecular mechanisms they play in physiological homeostasis and disease progression.

【Position description】
The Institute of Statistical Science of Academia Sinica is seeking visionary scientists to join our interdisciplinary research community. Applications are invited for tenure-track appointments as Full/Associate/Assistant Research Fellows (equivalent to Full/Associate/Assistant Professors in Universities). This tenure-track faculty position expects candidates to have new insights into statistics, data sciences, and computer science-related fields, including artificial intelligence.

【Job description】
Academia Sinica, Taiwan's most preeminent academic research institution, offers generous research funding, travel support, faculty housing, and other benefits. The Institute of Statistical Science provides a secure and stimulating research environment, with more than 30 faculty members, supportive administrative and IT teams, and many international visiting scholars annually. Unlike the universities, our faculty members have the freedom to choose to teach or not to teach.

Research projects related to plant stress signaling. Projects will involve molecular biology (cloning, construct preparation, Crispr/CAS9 mutagenesis, genotyping of mutant and transgenic plants) and biochemistry (recombinant protein expression, protein-protein interaction, protein-ligand interaction) as well as plant physiology experiments.

1.研究助理：協助研究或獨立研究。
Research Assistants: Assist in research-related tasks or work on an independent project.
2.博士後研究員：表觀遺傳與轉錄調控於發育及疾病之角色。
Postdoctoral Fellows: Conduct research on the roles of epigenetics and transcriptional regulation in development and diseases.

The applicant should specialize at least one of the following fields: (1) GeoAI; (2) Geo-Computing; (3) Computational Social Science; or, (4) Geographic Information Science related research.

大氣雲模式及降水粒子運動數值模擬與分析
Perform numerical simulation and analysis of atmospheric cloud model and precipitation particle motions.

1)Long-standing research interest in the crosstalk between immune and metabolic signaling, or immunometabolism, and its impact on physiological/pathophysiological processes. Examples of study areas include (but not limited to):
研究免疫和代謝信號之間的相互作用（即免疫代謝）及其對生理/病理過程的影響。
* Immunometabolism in tissue homeostasis (Science 368:eaat3987; J Clin Invest 123:261; Nat Med 18:1665)
* Mitochondrial dynamics in liver metabolism (JCI Insight 7:e150041; Cell Metab 22:709)
* Circadian/metabolic rhythm and metabolites mediated inter-organ communication (Nature 502:550)
* Mitochondrial bioenergetics in inflammatory activation and resolution of immune cells (eLife 9:e54090; Cell Metab 7:485
2)Studying the effect of gene regulation pathways on adipose tissue metabolism.
研究脂肪細胞代謝與基因訊號相關途徑之影響。
* Preadipocyte IL-13/IL-13R1 signaling regulates beige adipogenesis through modulation of PPAR activity (JCI 135(11):e169152)
3)Lab Management.
協助實驗室管理（包含：實驗室耗材訂購管理與經費核銷、化學藥品和抗體與引子歸檔、IACUC與IRB文件上傳等…）。
4)Ad-hoc tasks assigned by supervisor.
主管臨時交辦事項。

Responsibility: (either)
(1) Exploring epigenetic control in shaping sexual dimorphic circuit.
(2) Exploring the neural circuit mechanisms through Drosophila olfactory virtual reality system
(3) Exploring circuit integration of thermo-, hygro-, and olfactory sensation.

Responsibility: (either)
(1) Exploring epigenetic control in shaping sexual dimorphic circuit.
(2) Exploring the neural circuit mechanisms through Drosophila olfactory virtual reality system
(3) Exploring circuit integration of thermo-, hygro-, and olfactory sensation.