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1.Study metabolic processes underlying human diseases using multi-omics approaches, such as RNA-seq, proteomics, and metabolomics. 研究人類疾病背後的代謝過程。以RNA-seq資料, 蛋白質體學（Proteomics）與代謝體組學（Metabolomics）等多組體學分析代謝疾病。
2.Study the mechanistic link between immune and metabolic signaling, or immunometabolism, and its impact on physiological/pathophysiological processes. 研究免疫和代謝信號之間的相互作用（即免疫代謝）及其對生理/病理過程的影響。Examples of study areas include (but not limited to):
* Immunometabolism in tissue homeostasis (Science 368:eaat3987; J Clin Invest 123:261; Nat Med 18:1665)
* Mitochondrial dynamics in liver metabolism (JCI Insight 7:e150041; Cell Metab 22:709)
* Circadian/metabolic rhythm and metabolites mediated inter-organ communication (Nature 502:550)
* Mitochondrial bioenergetics in inflammatory activation and resolution of immune cells (eLife 9:e54090; Cell Metab 7:485
3)Lab Management and mouse colony maintenance. 協助實驗室事項（包含：實驗紀錄撰寫、論文發表、化學藥品或抗體歸檔等…）和實驗小鼠管理。

We are seeking passionate, proactive, and responsible Research Assistant to join our team in advancing bacteriophage therapy research!

【Research Focus and Responsibilities】

Project: Bacteriophage Protein for infectious diseases.

Research Objectives:

Study bacteriophage-host interaction
Produce bacteriophage proteins/enzymes for application in the treatment of infectious diseases and diagnosis
You will learn:

• Mater in Molecular biology and genetic engineering techniques.

• Protein applications in clinical medicine.

• Cryo-EM structural analysis and cryo-tomography of bacteriophages

【Lab info】

https://www.ibc.sinica.edu.tw/people/investigators/principal-investigators/todd-l-lowary/

https://www.ibc.sinica.edu.tw/people/investigators/principal-investigators/meng-chiao-ho/

Our research team is seeking 1~2 Research Associates to join us in exploring the evolution, ecology, and biology of eukaryotic microbes with key ecological roles on Earth. We focus on the interactions between microbes and their environment and utilize cutting-edge omics and bioinformatics tools to uncover their evolutionary trajectories and regulatory mechanisms. Currently, we are conducting an NSTC-funded project on marine algae, population variation, and warming. This position is open until filled.

顧銓研究室現正招募 1 至 2 位研究助理，加入我們探索真核微生物之演化、生態與生物學上的關鍵生態角色。我們著重微生物與環境之間的互動，並利用尖端的多體學與生物資訊工具發掘演化軌跡與調控機制。目前我們正執行國科會(NSTC)資助的計畫，研究海藻族群變異與暖化相關議題。本職缺即日起開放申請，額滿為止。

Research Topics
1. Population genomics and evolutionary biology of marine algae.
2. Effects of oceanographic and physico-chemical factors on algal distribution.
3. Genomic variation, transcriptomic regulation and physiological properties of lipid synthesis and host-virus interactions in marine algae.

研究主題
1. 海洋微藻族群基因體學與演化生物學
2. 海洋科學及海洋物理化學因子對微藻分佈的影響
3. 海洋微藻基因體變異,、轉錄體調控、生理特性對脂質生合成機制影響 ，以及對宿主-病毒交互作用關係。


Job description (Tasks are assigned flexibly; not all are required.)
-Culture and maintain microalgal and protist strains.
-DNA/RNA extraction, NGS libraries preparation, and perform sequencing.
-Design and conduct genomic, transcriptomic, or metabolomics experiments and analyses.
-Perform bioinformatic analyses, including genome assembly, annotation, and phylogenomic analysis, etc..
-May participate in field sampling during research cruises.
-Manage routine laboratory tasks and other assigned duties.

工作內容（彈性分配，非所有項目皆為必須）
-培養與維護微藻與原生生物菌株
-DNA/RNA抽取、NGS library建置與定序
-設計並執行基因體、轉錄體或代謝體實驗與數據分析
-生物資料分析，包括基因體組裝、註解、系統基因組學分析等
-研究航次期間，可能需參與現場採樣
-實驗室例行管理與其他交辦事項

All position.
To conduct an innovative research program in computational (broadly-defined), materials, energy, catalysis, chemical biology or other chemistry areas.

We investigate the mechanisms of telomere maintenance in regulating aging and cancer development. We utilize cell biology, mouse models, and next-generation sequencing techniques to explore the role of telomere function in aging-related diseases and cancer. Additionally, by integrating clinical medicine and medicinal chemistry, we aim to understand disease mechanisms and develop therapeutic approaches.

【Research Focus】
The Lab for Cell Dynamics (LCD) at Academia Sinica explores the biological functions of large-scale cell death during embryonic development, integrating advanced quantitative and imaging techniques. Our recent work (PMID: 38987590) reveals how developmental signals prime cells for death. We invite passionate junior scientists to join our team to investigate: How developmental cues orchestrate cell death during development.

我們正在尋找經驗豐富的行動應用程式開發人員，協助將 PQConnect 專案帶入 Android 和 iOS 作業系統。PQConnect 是一個全新且易於安裝的網路安全層，它能在有運行 PQConnect 的終端之間自動引入端到端的後量子加密技術。同時，它能與採用傳統密碼學的應用程式共同運作，並為任何已經內建後量子加密技術的使用者應用程式額外增加第二層的防護。PQConnect 在網路層的運作方式類似於 VPN，但它可容許的擴展性是大多數 VPN 應用程式所無法比擬的。如需了解更多資訊，請參考： https://www.pqconnect.net

Project Overview:
We are seeking a highly motivated Research Assistant to join our team in investigating the molecular mechanisms underlying bacterial peptidoglycan biosynthesis and morphological regulation. This project focuses on uncovering the biological and biochemical pathways that control bacterial shape and cell wall synthesis, with potential implications for antibiotic development.

You will be involved in experiments and analysis in areas such as:
1.Protein expression, purification, and biochemical characterization
2.Genetic engineering and molecular biology techniques
3.Microscopy and image-based analysis of bacterial morphology

Responsibilities
1.Conduct experiments
2.Assist in optimizing protocols and troubleshooting experimental challenges
3.Maintain laboratory records and contribute to data interpretation and figure preparation
4.Collaborate with lab members in experimental design and innovation
5.Participate in literature review, manuscript drafting, and conference preparation
6.Support lab maintenance and routine operations

We are seeking passionate, proactive, and responsible Research Assistants to join our team!

【Research Focus and Responsibilities】

Project: Immune cell experiments in the context of infectious diseases.

Research Objectives:

1. To investigate the host immune regulatory responses to mycobacterial infection.

2. To design and develop potential diagnostic or therapeutic strategies for clinical application in mycobacterial diseases.

Techniques and Tools:
-Immune cell isolation and activation techniques.
-Bacterial infection models and cellular functional assays.
-Molecular and immunological analysis techniques.
-Applications in clinical medicine.

This position presents a unique opportunity to work at the interface of basic and applied science, contributing to innovative solutions for infectious diseases.

Research projects related to plant stress signaling. Projects will involve molecular biology (cloning, construct preparation, Crispr/CAS9 mutagenesis, genotyping of mutant and transgenic plants) and biochemistry (recombinant protein expression, protein-protein interaction, protein-ligand interaction) as well as plant physiology experiments.

【Research Focus】
The Lab for Cell Dynamics (LCD) at Academia Sinica explores the biological functions of large-scale cell death during embryonic development, integrating advanced quantitative and imaging techniques. Our recent work (PMID: 38987590) reveals how developmental signals prime cells for death and how this process might influence aging. We invite passionate junior scientists to join our team to investigate:
1.How developmental cues orchestrate cell death during development.
2.The potential link between developmental death signaling and the aging process.

1. 暖化對魚類生活史的影響 Effects of warming on fish life-histories
2. 暖化下的魚類族群動態 Effects of warming on fish population dynamics