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【Research Focus】
The Lab for Cell Dynamics (LCD) at Academia Sinica explores the biological functions of large-scale cell death during embryonic development, integrating advanced quantitative and imaging techniques. Our recent work (PMID: 38987590) reveals how developmental signals prime cells for death and how this process might influence aging. We invite passionate junior scientists to join our team to investigate:
1.How developmental cues orchestrate cell death during development.
2.The potential link between developmental death signaling and the aging process.

1. 暖化對魚類生活史的影響 Effects of warming on fish life-histories
2. 暖化下的魚類族群動態 Effects of warming on fish population dynamics

Research Assistant Position in Structural Biology, AI, and Biochemistry

Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
We are hiring a full-time Research Assistant to join an interdisciplinary research at the cutting edge of structural biology, artificial intelligence, and biochemistry, with a central focus on the ubiquitin system in human diseases.

Position Overview
We are seeking a motivated Research Assistant with a Bachelor’s or Master’s degree in:
• Chemistry
• Biology
• Biotechnology
• or a related discipline
This is a hands-on role supporting ongoing research on:
• Protein ubiquitination and deubiquitination
• Structure-function analysis of enzymes
• AI-assisted protein design and drug discovery

Our Research Toolkit
• Cryo-Electron Microscopy (Cryo-EM)
• Nuclear Magnetic Resonance (NMR) spectroscopy
• X-ray Crystallography
• Biochemical assays & cell-based validation
• Deep learning for protein structure and ligand prediction (e.g., AlphaFold, DiffDock, ProteinMPNN, RFDiffusion, and more )

What We Offer
• A collaborative, high-energy research environment
• Access to state-of-the-art instrumentation and core facilities
• Opportunities to co-author publications and learn advanced techniques
• Training in both experimental and computational tools

Start Date
August or September 2025 (flexible, can be discussed)

Salary
Bachelor degree: NT$ 38388/month
Master degree: NT$ 44968/month
This position is subject to the Labor Standards Act.

How to Apply
Send your CV and a brief statement of interest to:
EMAIL: kpwulab@gmail.com
https://kpwulab.com

Research Topic: How glutamate and glutamine regulate plant growth and defense
Research Description:
Our laboratory uses molecular genetics approaches to study how plants sense and
respond to amino acids (glutamate and glutamine). We have found that, in addition to
being essential nutrients for plant growth, glutamate and glutamine can also enhance
plant defense responses. We welcome individuals who are interested in plant biology
and plan to pursue advanced degrees to join our team in exploring the novel functions
of amino acids in plants.

想將你的專業知識，應用在新藥研發與代謝研究領域嗎？
歡迎加入我們的 NMR 核心設施團隊，成為推動藥物分析及科學突破的重要一員！

1. 操作先進 NMR 儀器，負責代謝物、小分子等樣品之光譜收集、數據分析及研究，協助揭示化合物的結構奧秘。
2. 與醫院實驗室緊密合作，整合各類實驗數據，為精準醫療提供更完整的分析解決方案。
3. 協助整理研究數據，撰寫成果報告、簡報或發表內容，為團隊提供專業且精準的技術支持。
4. 協助儀器的日常維護與檢測，以及核心設施的行政支援工作，確保核心穩定運作。

加入我們，除了能接觸最先進的科學儀器，也將成為新藥研究、謝體學及多元領域分析的關鍵高手，與我們一起探索化學及醫學世界的無限可能！

Responsibilities for postdoctoral fellow:
• Leading independent research, design and carrying out well controlled, reproducible experiments which address well-developed hypotheses.
• Work closely with other team members and external collaborators.
• Present progress internally and externally through conferences.
• Writing manuscripts and assisting with grant applications.

Responsibilities for research assistant:
• Collaborating with team members to design and establish various biochemical assays, molecular biological techniques, mouse colony management and assist mouse-based experimental techniques when needed.
• Overseeing day-to-day lab operations, provide administrative support, maintenance of safety standards, restock and purchasing, databases and standard operating procedures, and general organization of the lab.

The Cheung Lab, relocating from the Francis Crick Institute (London, UK) to the Genomics Research Center (GRC), Academia Sinica (Taipei) in August 2025, is seeking highly motivated and creative researchers to join our team. In GRC, you will be joining a group of enthusiastic postdocs and PhD students with diverse expertise in cancer research and metabolism and will have access to state-of-the-art approaches and resources in GRC as well as other AS institutes.

Our goal is to understand how cancer cells communicate with their immediate microenvironment as well as distal host tissues and organs to regulate metabolic stress and redox homeostasis in tumours to facilitate growth and metastasis, focusing on pancreatic cancer (Cheung et al. PNAS 2024, Cheung and Vousden Nat Rev Cancer 2022, Cheung et al. Cancer Cell 2020, Cheung et al. Genes Dev 2016, Cheung et al. Developmental Cell 2013). We employ functional genomics, metabolomics, ex vivo organoid models, animal models of cancer, and single cell sequencing to uncover new mechanisms of disease and therapeutic targets. Our work seeks to reveal novel strategies that target both cancer cells and host tissues, offering a more refined, systemic approach to cancer treatment.

Research Associate Positions at IMB, Academia Sinica (Starting October 2025)
My lab at the Institute of Molecular Biology (IMB), Academia Sinica, focuses on the rapid evolution of essential genes and chromosome structures. We are particularly interested in the paradox of how genes and chromosomal features critical for survival and reproduction, typically expected to be evolutionarily conserved, can instead evolve rapidly under strong positive selection. To investigate this, we integrate genetics, genomics, and cytology to uncover the causes and consequences of this phenomenon.
We are seeking 1–2 highly motivated B.S. or M.S.-level research associates to join the lab and contribute to new and ongoing projects. Successful candidates will have opportunities to co-author publications and are encouraged to lead independent research projects. Based on performance, there will be opportunities to attend international conferences and visit collaborating labs in the U.S. or Canada. I am committed to supporting career development and mentorship for all team members.

Responsibilities:
•Perform basic molecular biology experiments:
oPCR, molecular cloning, DNA and RNA extraction, sequencing
•Assist with lab management:
oMedia preparation, ordering supplies, and equipment maintenance
•Take initiative to lead or contribute to research projects
•Present work in lab meetings and provide weekly updates

數據分析與管理
Perform data analysis and management.

本實驗室利用蘚苔為實驗材料，致力於研究陸生植物的外表形態環境適應及其訊號傳遞的演化過程機制。本計畫會用到分子生物、遺傳、基因組編輯、顯微鏡觀察及蛋白純化等技術。歡迎對植物研究工作有熱忱的你加入。
The lab is using moss (Physcomitrium patens) as a model to investigate various developmental biology-related questions in plants. The lab routinely employs techniques such as genetic manipulations, protein expression/purification, and confocal microscopy observation. We encourage those interested in plant biology to be part of the team.
實驗室網站：https://sites.google.com/view/kock-lab/home

ASIAA CASA Development Center (ACDC) is a software team for the ALMA-Taiwan project, focusing on quality software development to boost science productivity. Please check https://cartavis.org to see what we are actively working on. We are looking for one software developer and one computing system manager with enthusiasm and interests in astronomy to join our team.

Launched in September 2022, the Kamino Lab investigates the fundamental principles that govern cellular behavior and information processing. With Keita’s background in physics, our lab integrates diverse approaches, including molecular genetics, theoretical physics, microscopy, and machine learning. We are currently seeking two research assistants with strong backgrounds in related fields and a passion for interdisciplinary research. Potential areas of exploration include, but are not limited to:
- Live-cell analysis of cellular behaviors using advanced microscopy techniques
- Theoretical analysis of cell-signaling dynamics using probability, information theory, and dynamical systems theory
- Image and time-series analysis using advanced statistical methods, including machine learning
- Development of cutting-edge measurement tools in microscopy and microfluidics

We are looking for a 1-2 year short term research assistant on molecular biology. You will be involved in any of the following projects:

Topic 1 Plant synthetic biology: To build a synthetic polarity circuit in plant root hair to hijack and modulate root hair tip growth.

Topic 2: Fungal cell polarity: To elucidate how differences in the polarity proteins in yeast and filamentous fungi influence the spatial temporal dynamics of cell polarity.

Topic 3: Bacterial communication within biofilms: Bacteria form multicellular communities called biofilms. Biofilms develop using patterned cell differentiation, similar to embryogenesis. This project aims to elucidate how oscillators within individual bacteria couple with each other to form synchronized patterns collectively in a biofilm.

Who we are looking for: People who are 1. experienced and skilled in molecular cloning, specifically making plasmid constructs, and 2. want to learn more.

What you will learn: All of the topics above heavily rely on the crosstalk between Dynamic Systems Theory, and Molecular Cell Biology. The lab is integrally good at Live Cell Imaging, Image Analysis, Coding, Dynamic Modeling, and Microfluidics. We encourage you to see this as an opportunity to learn something new for your future career.