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大氣雲模式及降水粒子運動數值模擬與分析
Perform numerical simulation and analysis of atmospheric cloud model and precipitation particle motions.

1、 執行業界及學研界之小分子新藥與化合物合成委託專案。
2、 依據目標化合物進行文獻搜尋與合成路徑評估，執行多步驟有機合成、反應條件優化、化合物純化、分析及結構確認。
3、 定期彙整專案進度與實驗結果，並與合作團隊進行跨領域技術討論。
4、 參與核心設施相關運作與管理，以及其他主管交辦事項。

研究主題: 
麩胺酸與麩醯胺酸如何調控植物的生長與防禦
研究內容: 
本實驗室以分子遺傳的研究方法，探討植物對胺基酸（麩胺酸與麩醯胺酸
）的感應與訊息傳導。我們發現麩胺酸與麩醯胺酸除了是植物生長所必需的營
養成分，也可以促進植物的防禦反應，歡迎具有獨立研究能力的博士後研究人
員加入我們的行列，一起探索植物胺基酸的新功能。
所有博士後參與研發的主題與材料，以及實驗室其它的研究課題，在該博
士後獲得教職或成為獨立的研究人員之後，都可以帶走，在下階段的職涯繼續
研究。
Research Topic: How glutamate and glutamine regulate plant growth and defense
Research Description:
Our laboratory uses molecular genetics approaches to study how plants sense and respond to
amino acids (glutamate and glutamine). We have discovered that, in addition to being essential
nutrients for plant growth, glutamate and glutamine can also enhance plant immune responses.
We welcome postdoctoral researchers with independent research capabilities to join us in
exploring the novel functions of amino acids in plants.
All postdoctoral researchers are welcome to take the research topics, materials, and any other
related projects they worked on during their time in our lab to continue developing them in the
next stage of their academic careers, such as in faculty or independent research positions.

以合成生物學、基因體學、轉錄體學、蛋白質體學、代謝體分析、演化學、及AI輔助，探討促進植物固碳及增加光合作用產量的調控因子、代謝途徑、與分子機制。透過基因轉殖技術，將可能促進光合作用與生長的因子導入藍綠菌及植物中，研究特定分子或合成途徑對優化光合效率、生長勢與產量的效力，以提出能促進光合作用增加產量的新法。
We are studying plant synthetic biology and metabolic engineering aiming to enhance photosynthetic carbon fixation, growth, and yield.

The major research interests in the LAI lab are to understand the molecular mechanisms underlying how bacterial pathogens deploy protein secretion systems for survival at its ecological niche and successful infection inside the plant host. We study the mechanistic and biological insights of the two major protein secretion nanomachines, type IV and type VI secretion systems (T4SS and T6SS), in Agrobacterium tumefaciens, the causal agent of crown gall disease and powerful gene transfer tool. We also aim to identify novel agrobacterial and plant genes critical for plant transformation and gene editing. The knowledge may provide new insights to improve Agrobacterium-mediated plant transformation and translational applications in biomedicine and/or agriculture.

The postdoc will carry out a two-year research grant to study the antibacterial T6SS with focuses to investigate the T6SS evolution and assembly mechanisms.

The LAI lab provides the research environments and expertise on studies of protein secretion and pathogen-plant interactions using various tools including genetics/genomics, molecular biology, biochemistry/proteomics, and cell biology. The research may expand to study structural aspects of T6SS-assocaited protein complex using X-ray crystallography and cryoEM. The postdoc is also encouraged to develop an independent project and will be trained to serve as a mentor toward an independent investigator. The LAI lab is also active in international collaborations, which will bring opportunities for abroad training.

1.研究助理：協助研究或獨立研究。
Research Assistants: Assist in research-related tasks or work on an independent project.
2.博士後研究員：表觀遺傳與轉錄調控於發育及疾病之角色。
Postdoctoral Fellows: Conduct research on the roles of epigenetics and transcriptional regulation in development and diseases.

Responsibility: (either)
(1) Exploring epigenetic control in shaping sexual dimorphic circuit.
(2) Exploring the neural circuit mechanisms through Drosophila olfactory virtual reality system
(3) Exploring circuit integration of thermo-, hygro-, and olfactory sensation.

Highly desirable:
• Metabolomics: Proficiency in Mass Spectrometry or NMR-based metabolic profiling and analysis.
• Systemic Interaction: Experience in studying the Immune System or the Nervous System.
• Expertise in designing and executing complex in vivo experiments. A strong background in developing, breeding, and analyzing genetically modified animal models applied to cancer biology or neuroscience.

The position is to develop and apply nonlinear ultrafast laser spectroscopies to studies of quantum geometric phenomena and ultrafast electromagnetic responses in topological quantum metals.

The candidate will be devoted to execute laser spectroscopic experiments, analyze the data, and write manuscripts.

1. Positions will entail independent projects in research topics spanning R-loop dynamics, genome organization, DNA damage repair, and cancer progression and drug resistance.
2. Perform molecular biology and cell biology experiments (e.g., tissue culture, CRISPR cloning, library preparation).
3. Conduct proteomics and genomics-related experiments.
4. Analyze sequencing and genomics data using Python and R
5. Assist in laboratory organization, inventory management, and ordering reagents.
1.本職位將進行獨立研究計畫，研究主題涵蓋 R-loop 動態、基因體結構、DNA 損傷修復，以及癌症進展與抗藥性等領域。
2.執行分子生物與細胞生物學實驗（如細胞培養、CRISPR 克隆、定序文庫製備等）。
3.進行蛋白質體學與基因體相關實驗。
4.使用 Python 或 R 進行定序資料與基因體數據分析。
5.協助實驗室日常管理（試劑訂購、庫存整理等）。

The NanoBioPhotonics Laboratory (NBP Lab) is dedicated to developing advanced optical microscopy technologies and integrating them with chemical and biological techniques. Through interdisciplinary approaches, the lab quantitatively investigates nanoscale structures and dynamics in living cells. Responsibilities include optical system development, operation, and optimization, live-cell experiments, image and data analysis, execution of research projects, and publication of research results.

We conduct research in diverse areas of computational biology, data science and machine learning, including multi-omics data integration of cancers, optimal treatment design for heterogeneous and evolving tumors, single-cell omics data analysis, evolution of biomolecular networks and human populations, topological characterization of networks, and unsupverised learning using deep neural networks. Group members will gain experience in learning domain knowledge, performing scientific reasoning, formulating and solving mathematical models, developing algorithms, writing programs and using existing packages, collecting and analyzing big data, and interacting closely with international and domestic collaborators. We look for motivated persons curious about open scientific problems and willing to dedicate energy and time to solve them.