Academia Sinica Logo

The major research interests in the LAI lab are to understand the molecular mechanisms underlying how bacterial pathogens deploy protein secretion systems for survival at its ecological niche and successful infection inside the plant host. We study the mechanistic and biological insights of the two major protein secretion nanomachines, type IV and type VI secretion systems (T4SS and T6SS), in Agrobacterium tumefaciens, the causal agent of crown gall disease and powerful gene transfer tool. We also aim to identify novel agrobacterial and plant genes critical for plant transformation and gene editing. The knowledge may provide new insights to improve Agrobacterium-mediated plant transformation and translational applications in biomedicine and/or agriculture.

The postdoc will carry out a two-year research grant to study the antibacterial T6SS with focuses to investigate the T6SS evolution and assembly mechanisms.

The LAI lab provides the research environments and expertise on studies of protein secretion and pathogen-plant interactions using various tools including genetics/genomics, molecular biology, biochemistry/proteomics, and cell biology. The research may expand to study structural aspects of T6SS-assocaited protein complex using X-ray crystallography and cryoEM. The postdoc is also encouraged to develop an independent project and will be trained to serve as a mentor toward an independent investigator. The LAI lab is also active in international collaborations, which will bring opportunities for abroad training.

We are looking for a post-doc for a project to examine evolution and speciation in Caenorhabditis nematodes using molecular and genetic approaches.
我們欲招募一名博士後研究，參與一項利用分子和遺傳學方法研究Caenorhabditis 屬線蟲演化與物種形成的計畫。

Postdoctoral Researcher in Family Change and Low Fertility in East Asia
The Institute of Sociology, Academia Sinica invites applications for a postdoctoral researcher to join a research program on family change, partnership formation, and low fertility in Taiwan and East Asia over a 2-year period (with renewal possibility). The position offers opportunities to develop independent publications within the broad themes of the project. The position involves no teaching load and also provides mentorship toward publication in leading journals. The position is particularly suitable for early-career researchers seeking to establish an independent publication record in family demography and population studies.

The research program seeks to understand how contemporary demographic change—including delayed partnership formation, rising singlehood, marriage, cohabitation, changing gender relations, persistent low fertility, birth outcomes, and social inequalities—is reshaping family life in Taiwan and East Asia. Through nationally representative survey data and comparative research, we aim to contribute to broader theoretical debates on family change, inequality, and demographic transformation.

Research themes
•singlehood and unpartnered adults;
•partnership formation and marriage;
•fertility intentions;
•gender, values, and family change;
•inequality in low-fertility societies;
•Taiwan and comparative East Asian demography.

Responsibilities
•develop independent and collaborative research papers;
•analyze survey and/or register-based demographic data;
•contribute to international journal manuscripts;
•participate in workshops, conferences, and cross-country research meetings;
•help strengthen the broader research program.

Molecular Mechanisms of Genome Stability
The Liang Laboratory at the Institute of Biological Chemistry, Academia Sinica, investigates the molecular mechanisms that preserve genome integrity during DNA replication and DNA repair. We combine structural biology, biochemistry, cell biology and functional genomics using state-of-the-art experimental approaches to understand how cells respond to replication stress, repair damaged DNA and maintain chromosome integrity. Our goal is to uncover fundamental mechanisms of genome maintenance while identifying new therapeutic opportunities for cancer.
Current research areas include:
• Break-induced replication (BIR)
• Holliday junction processing
• DNA replication stress
• Alternative lengthening of telomeres (ALT)
Why Join the Liang Laboratory?
Members of the Liang Laboratory will have the opportunity to:
• investigate fundamental questions in genome stability with broad implications for human health and disease
• develop expertise across structural biology, biochemistry, molecular biology, cell biology and functional genomics
• receive close scientific mentorship while developing independence and leading their own research projects
• collaborate with leading researchers in Taiwan and internationally
• present their work at international conferences and publish in leading international journals
We are committed to fostering an open, collaborative and supportive research environment where members are encouraged to think critically, develop their own ideas and grow into independent scientists.

B細胞的發育分化與恆定，及其與疾病關聯性之研究。
使用人類檢體，基因剔除或轉殖小鼠動物模式實驗來研究B細胞功能，及於生理恆定與疾病進程所扮演之角色與分子機制。

Research and Work Content
• Research Focus: Research on B cell development, differentiation, and homeostasis, and their relationship with diseases.
• Job Description: Using human specimens , knockout or transgenic mouse models to study B cell function and the molecular mechanisms they play in physiological homeostasis and disease progression.

1.研究助理：協助研究或獨立研究。
Research Assistants: Assist in research-related tasks or work on an independent project.
2.博士後研究員：表觀遺傳與轉錄調控於發育及疾病之角色。
Postdoctoral Fellows: Conduct research on the roles of epigenetics and transcriptional regulation in development and diseases.

大氣雲模式及降水粒子運動數值模擬與分析
Perform numerical simulation and analysis of atmospheric cloud model and precipitation particle motions.

Responsibility: (either)
(1) Exploring epigenetic control in shaping sexual dimorphic circuit.
(2) Exploring the neural circuit mechanisms through Drosophila olfactory virtual reality system
(3) Exploring circuit integration of thermo-, hygro-, and olfactory sensation.

Highly desirable:
• Metabolomics: Proficiency in Mass Spectrometry or NMR-based metabolic profiling and analysis.
• Systemic Interaction: Experience in studying the Immune System or the Nervous System.
• Expertise in designing and executing complex in vivo experiments. A strong background in developing, breeding, and analyzing genetically modified animal models applied to cancer biology or neuroscience.

The position is to develop and apply nonlinear ultrafast laser spectroscopies to studies of quantum geometric phenomena and ultrafast electromagnetic responses in topological quantum metals.

The candidate will be devoted to execute laser spectroscopic experiments, analyze the data, and write manuscripts.

1. Positions will entail independent projects in research topics spanning R-loop dynamics, genome organization, DNA damage repair, and cancer progression and drug resistance.
2. Perform molecular biology and cell biology experiments (e.g., tissue culture, CRISPR cloning, library preparation).
3. Conduct proteomics and genomics-related experiments.
4. Analyze sequencing and genomics data using Python and R
5. Assist in laboratory organization, inventory management, and ordering reagents.
1.本職位將進行獨立研究計畫，研究主題涵蓋 R-loop 動態、基因體結構、DNA 損傷修復，以及癌症進展與抗藥性等領域。
2.執行分子生物與細胞生物學實驗（如細胞培養、CRISPR 克隆、定序文庫製備等）。
3.進行蛋白質體學與基因體相關實驗。
4.使用 Python 或 R 進行定序資料與基因體數據分析。
5.協助實驗室日常管理（試劑訂購、庫存整理等）。

The NanoBioPhotonics Laboratory (NBP Lab) is dedicated to developing advanced optical microscopy technologies and integrating them with chemical and biological techniques. Through interdisciplinary approaches, the lab quantitatively investigates nanoscale structures and dynamics in living cells. Responsibilities include optical system development, operation, and optimization, live-cell experiments, image and data analysis, execution of research projects, and publication of research results.