Academia Sinica Logo

【Research Focus】
The Lab for Cell Dynamics (LCD) at Academia Sinica explores the biological functions of large-scale cell death during embryonic development, integrating advanced quantitative and imaging techniques. Our recent work (PMID: 38987590) reveals how developmental signals prime cells for death and how this process might influence aging. We invite passionate junior scientists to join our team to investigate:
1.How developmental cues orchestrate cell death during development.
2.The potential link between developmental death signaling and the aging process.

1. 暖化對魚類生活史的影響 Effects of warming on fish life-histories
2. 暖化下的魚類族群動態 Effects of warming on fish population dynamics

研究聚焦於離線RL(Reinforcement Learning)、穩健性RL模型，以及在金融與機器人等真實場域的應用。

主要職責
- 進行 RL 相關研究
- 主導或參與頂尖國際會議／期刊投稿
- 協助撰寫研究計畫並推動產學合作
We seek a highly motivated postdoctoral researcher who wants to push the frontier of sequential decision-making under uncertainty and deploy results in impactful domains.

- Conduct independent and collaborative research on RL
- Co-supervise graduate students and research assistants
- Lead or contribute to top-tier conference/journal submissions
- Assist with grant writing and industry collaborations

本實驗室致力於運用分子生物學的方法，研究快速演化的基因與染色體結構。我們對於具有重要功能的基因與染色體結構在演化上理應高度保守，卻仍觀察到快速演化的現象感到好奇，並希望進一步理解背後的機制與演化動力。我們目前的研究發現自私的基因可以解釋部分這些現象。我們的研究將針對這些矛盾現象進行系統性探討，並結合不同層次的實驗方法深入剖析其生物學意涵。 本實驗室將於 2025 年 10 月正式成立，現誠徵博士後助理新實驗室進行主導，並發展獨立研究計畫，並有機會參與論文發表並獲得作者資格。我將會視情況提供參與國際研討會或參與國外合作者實驗室的機會。我將提供職涯發展的建議及協助。 工作內容： -主導獨立規劃並執行研究計畫 -撰寫論文並協助申請研究計劃 -鼓勵發展獨立研究計劃 -帶領並指導年輕實驗室成員 -參與實驗室會議並定期報告研究進度 -每週更新實驗進展

My lab at the Institute of Molecular Biology (IMB), Academia Sinica, focuses on the rapid evolution of essential genes and chromosome structures. We are particularly interested in the paradox of how genes and chromosomal features critical for survival and reproduction, typically expected to be evolutionarily conserved, can instead evolve rapidly under strong positive selection. To investigate this, we integrate genetics, genomics, and cytology to uncover the causes and consequences of this phenomenon.

We are seeking 1 postdoctoral researcher to conduct and lead research projects. Candidates will earn authorship on resulting publications and will be strongly encouraged to develop and lead independent projects. Successful candidates will have opportunities to attend international conferences and visit collaborator labs in US or Canada. I’m strongly committed to supporting career development and mentorship for all team members.

Responsibilities:

Lead and contribute to research projects, including international collaborations
Draft and revise manuscripts for publication; assist in grant writing
Develop and pursue independent research directions
Mentor junior lab members
Present data at lab meetings and provide regular project updates
Maintain weekly progress reports on experiments and analysis

Research Topic: How glutamate and glutamine regulate plant growth and defense
Research Description:
Our laboratory uses molecular genetics approaches to study how plants sense and respond to
amino acids (glutamate and glutamine). We have discovered that, in addition to being essential
nutrients for plant growth, glutamate and glutamine can also enhance plant immune responses.
We welcome postdoctoral researchers with independent research capabilities to join us in
exploring the novel functions of amino acids in plants.
All postdoctoral researchers are welcome to take the research topics, materials, and any other
related projects they worked on during their time in our lab to continue developing them in the
next stage of their academic careers, such as in faculty or independent research positions.

Responsibilities for postdoctoral fellow:
• Leading independent research, design and carrying out well controlled, reproducible experiments which address well-developed hypotheses.
• Work closely with other team members and external collaborators.
• Present progress internally and externally through conferences.
• Writing manuscripts and assisting with grant applications.

Responsibilities for research assistant:
• Collaborating with team members to design and establish various biochemical assays, molecular biological techniques, mouse colony management and assist mouse-based experimental techniques when needed.
• Overseeing day-to-day lab operations, provide administrative support, maintenance of safety standards, restock and purchasing, databases and standard operating procedures, and general organization of the lab.

The Cheung Lab, relocating from the Francis Crick Institute (London, UK) to the Genomics Research Center (GRC), Academia Sinica (Taipei) in August 2025, is seeking highly motivated and creative researchers to join our team. In GRC, you will be joining a group of enthusiastic postdocs and PhD students with diverse expertise in cancer research and metabolism and will have access to state-of-the-art approaches and resources in GRC as well as other AS institutes.

Our goal is to understand how cancer cells communicate with their immediate microenvironment as well as distal host tissues and organs to regulate metabolic stress and redox homeostasis in tumours to facilitate growth and metastasis, focusing on pancreatic cancer (Cheung et al. PNAS 2024, Cheung and Vousden Nat Rev Cancer 2022, Cheung et al. Cancer Cell 2020, Cheung et al. Genes Dev 2016, Cheung et al. Developmental Cell 2013). We employ functional genomics, metabolomics, ex vivo organoid models, animal models of cancer, and single cell sequencing to uncover new mechanisms of disease and therapeutic targets. Our work seeks to reveal novel strategies that target both cancer cells and host tissues, offering a more refined, systemic approach to cancer treatment.

Launched in September 2022, the Kamino Lab investigates the fundamental principles that govern cellular behavior and information processing. With Keita’s background in physics, our lab integrates diverse approaches, including molecular genetics, theoretical physics, microscopy, and machine learning. We are currently seeking two research assistants with strong backgrounds in related fields and a passion for interdisciplinary research. Potential areas of exploration include, but are not limited to:
- Live-cell analysis of cellular behaviors using advanced microscopy techniques
- Theoretical analysis of cell-signaling dynamics using probability, information theory, and dynamical systems theory
- Image and time-series analysis using advanced statistical methods, including machine learning
- Development of cutting-edge measurement tools in microscopy and microfluidics

We are a new interdisciplinary laboratory with an excellent research and work environment, welcoming highly motivated individuals to join our team. Our primary research explores biochemical and biophysical processes through a range of advanced experimental techniques. We apply cutting-edge microscopy to investigate bacterial energetics, chemotaxis, and motility. By integrating physical modeling and simulation, we push the boundaries of discovery, venturing into areas previously unexplored.

1.研究助理：協助研究或獨立研究。
Research Assistants: Assist in research-related tasks or work on an independent project.
2.博士後研究員：表觀遺傳與轉錄調控於發育及疾病之角色。
Postdoctoral Fellows: Conduct research on the roles of epigenetics and transcriptional regulation in development and diseases.

The lab of Ka Wai Ma is inviting application working on plant-
microbiota research. The lab is using different model systems and the
associated culture collection to understand the principles governing
plant-microbiota homeostasis. The lab routinely uses omics
techniques including amplicon sequencing, transcriptomics and
reconstitution system. The lab is currently looking for a motivated
candidate to work on a CRISPR editing project. The project aims to
use CRISPR technology to perform gene editing on crops with
subsequent phenotyping.
The position is opened until filled
馬家威實驗室現誠聘研究助理/博士後，從事植物微生物相研究。本實
驗室使用不同的模型系統和相關的微生物庫進行植物微生物相重組實驗
以了解植物微生物群互動平衡機理。實驗室大量使用比如包括擴增子測
序、轉錄組學技術。本實驗室目前正在尋找助理/博士後從事 CRISPR
編輯專案。該專案旨在使用 CRISPR 技術對作物進行基因編輯，並進
行表型分析。

Lab Manager, Genomics Core Facility, Institute of Molecular Biology
Job Description
1.Provide genomics research technical services, including next-generation sequencing (NGS), third-generation sequencing, and spatial transcriptomics experiments (DNA/RNA sample processing, QC analysis, NGS library preparation, new technology development, operation of high-throughput sequencers, qPCR systems, etc.).
2.Customized experimental design, consultation, and development of new technologies.
3.Manage shared instruments and provide training in equipment operation and data analysis.

Core Facility Website https://www.imb.sinica.edu.tw/mdarray/index.html