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信件收發、公文傳遞、文書處理及臨時交辦事項。

The major research interests in the LAI lab are to understand the molecular mechanisms underlying how bacterial pathogens deploy protein secretion systems for survival at its ecological niche and successful infection inside the plant host. We study the mechanistic and biological insights of the two major protein secretion nanomachines, type IV and type VI secretion systems (T4SS and T6SS), in Agrobacterium tumefaciens, the causal agent of crown gall disease and powerful gene transfer tool. We also aim to identify novel agrobacterial and plant genes critical for plant transformation and gene editing. The knowledge may provide new insights to improve Agrobacterium-mediated plant transformation and translational applications in biomedicine and/or agriculture.

The postdoc will carry out a 3-year NSTC grant to study the molecular mechanisms of T6SS offense and defense with focuses to investigate how the recipient cell factors involved in regulating the toxicity of T6SS antibacterial effector.

The LAI lab provides the research environments and expertise on studies of protein secretion and pathogen-plant interactions using various tools including genetics/genomics, molecular biology, biochemistry/proteomics, and cell biology. The research may expand to study structural aspects of effector-associated complex using X-ray crystallography and cryoEM through collaborations with the assistance of Academia Sinica Protein Clinic and Cryo-EM Center. The postdoc is also encouraged to develop an independent project and will be trained to serve as a mentor toward an independent investigator. The LAI lab is also active in international collaborations, which will bring opportunities for abroad training.

Exploring the neural circuit mechanisms through Drosophila olfactory virtual reality system

The Institute of Biological Chemistry (IBC) at Academia Sinica, Taiwan (www.ibc.sinica.edu.tw) seeks outstanding candidates to fill tenure-track faculty positions. While our primary focus is on hiring at the Assistant Research Fellow level, we also welcome applications from more experienced candidates, including those at the Research Fellow level. The Institute has a long tradition of excellence in research at the biology/chemistry interface, in particular protein biochemistry, structural biology, glycoscience and the study of other post-translational modifications.

In this search, we are seeking candidates whose research interests complement existing research programs in the Institute. Individuals with expertise in quantitative or computational biology who are able to address the dynamics and complexity of biochemical problems are of particular interest. Experience integrating AI-based technologies into research projects is also highly desired. However, candidates with any relevant research programs will be considered. The chosen candidates will receive an appointment at the Institute of Biochemical Sciences, National Taiwan University (ibs.ntu.edu.tw), along with substantial start-up funds, ongoing intramural support, and full access to all shared resources in Academia Sinica.

Application materials should include:
1) A cover letter with the names of three referees who will write on the applicant’s behalf;
2) A curriculum vitae;
3) A statement of research accomplishments; and
4) A proposal for future research. Application materials should be combined into a single PDF file and sent to the Chair of Recruitment Committee, c/o Ms. Pei-Ru Liao (email: prliao@gate.sinica.edu.tw).
The applicant should arrange for the letters from the three referees to be sent directly to prliao@gate.sinica.edu.tw.

Screening of applications will begin on July 15, 2024 and will continue until the positions are filled.

IBC is dedicated to fostering a diverse and inclusive workforce, and we actively encourage applications from individuals of all backgrounds. We particularly welcome applications from women, indigenous peoples, individuals from visible minority groups, persons with disabilities, and those of any sexual orientation or gender identity. Proficiency in Mandarin Chinese is not a prerequisite for application.

中研院冷凍電子顯微鏡設施主要目標為協助蛋白質結構解析與細胞內的超微結構之研究，進而解決重要生技議題及重大疾病問題，現尋求可長期穩定協助設施運作之人才。

職務名稱：
博/碩士級儀管人員

工作內容：
1. 儀器效能最佳化及研究合作執行（博士級）
2. 設施例行維護運作
3. 冷凍電顯樣品製備與上機、協助使用者儀器操作
4. 提供專業技術諮詢及教育訓練
5. 定期彙報、統計資料等行政業務
6. 臨時交辦事項

Academia Sinica Cryo-EM Facility aims to assist analyzing protein structure and cellular ultrastructure for further solutions of bio-technology issues and serious disease problems. We sincerely recruit professionals to join us.

Title:
PhD/MS Facility Manager

Responsibilities:
1. Optimize equipment efficiency and conduct collaborative projects (for PhD)
2. Routine facility operation
3. Cryo-EM sample preparation, data collection, and user operation assistance
4. Technical consultation and training for users
5. Routine administrative reports, such as service effectiveness analysis
6. Temporary tasks

【研究方向與工作內容】
傳染性疾病的診斷與治療相關的研究

結合獨特的細菌醣質化學合成加上重組蛋白的生產與結構解析
研究 - 噬菌體的蛋白作為傳染性疾病之醣質快篩診斷和醣酵素的產業應用。
噬菌體是一種具高專一性且能殺死細菌的病毒，藉由其表面蛋白去辨認細菌的醣質，入侵並破壞特定的細菌,因此噬菌體號稱能拯救人類的病毒。
本研究，結合特有的醣質化學合成與重組蛋白的結構解析，去快速篩選噬菌體的醣結合蛋白。由於噬菌體藉由醣結合蛋白辨認特定的細菌。此研究能夠作為快篩試劑應用於細菌病原的診斷，另外可能應用在噬菌體治療傳染性疾病。實驗室成員除了利用分子生物學，負責重組蛋白質的生產與外，更有機會學習蛋白質QA/QC和高階蛋白質結構解析技術外，更有機會學習，冷凍電顯結構解析。

The Todd Lowary & Joseph Ho Laboratory at the Institute of Biochemical Sciences, Academia Sinica in Taipei is seeking a master-level research assistant or post-doc to join our team. Our research focuses on the prevention/diagnosis of infectious diseases and the development of related industrial applications, combining unique bacterial carbohydrate chemistry with recombinant protein production and phage structural analysis.
The successful candidate will work on a project investigating bacteriophages, viruses that are highly specific and can kill bacteria. By identifying the bacterial carbohydrates through their surface proteins, bacteriophages can invade and destroy specific bacteria. Our research combines unique carbohydrate chemistry synthesis with structural analysis of recombinant proteins to quickly screen for bacteriophage glycan-binding proteins.


【實驗室相關資訊】For more information about our laboratory, please visit our websites:
https://lowarylab.ca/
https://www.holab.org/home

We are a group of interdisciplinary scientists, investigating regulatory logic underlying emergent properties of biochemical systems, including oscillators, switches, and trigger waves especially those that control cell death, quiescence and metabolic homeostasis. We use quantitative approaches including CRISPR-mediate cell engineering, single cell time-lapse imaging, mathematical modeling of dynamic systems, time series analysis, microfluidic engineering, etc., to study human cells (cancer cells and neuronal cells) under metabolic and drug challenges. We aim to develop strategies to control cell behavior for the treatment of aging-related diseases (cancer and neurodegeneration).

Using mouse models and human iPSC system, together with scRNA/ATAC-seq technique to decipher the molecular mechanism for aging and healthy longevity. We also aim to uncover the new method to cure motor neuron disease by gene therapy. We strongly encourage candidates interested in molecular mechanisms of gene regulation as related to non coding RNAs should apply. Candidates experienced in ESC/iPSC cell culture and mouse embryo manipulation are preferred, but not required.

Using mouse models and human iPSC system, together with scRNA/ATAC-seq technique to decipher the molecular mechanism for Neurodegeneration and Aging. We also aim to uncover the new method to cure motor neuron disease by gene therapy. We strongly encourage candidates interested in molecular mechanisms of gene regulation as related to non coding RNAs should apply. Candidates experienced in mouse experiments and ESC/iPSC cell culture are preferred, but not required.

Lin lab is recruiting a research assistant/lab manager. Our lab is working on microfluidic cell culture, time-lapse microscopy, and image analysis. We are particularly interested in applicants with molecular biology, microbiology, physics or mechanical/electrical engineering training background.

The job will be mainly research works and potentially with administrative works (optional). Based on applicants’ expertise and career plan, we could choose suitable kinds of tasks and duties for you.

Lin lab is recruiting researchers who are interested in systems biology and biophysics. We welcome people from various research backgrounds including quantitative biology, microfluidic engineering, mathematical modeling, etc.

Our lab will explore multiple research directions, including: (1) Characterizing metabolic dynamics and cell growth in E. coli or S. pombe at the single-cell level, with time-lapse microscopy and microfluidics cell culture. (2) Theoretical and computational studies for cell growth and reaction networks, focusing on cellular resource/energy allocation, metabolic network evolution, autocatalytic systems, nonlinear and nonequilibrium physics, etc.

I have been benefited from the interdisciplinary trainings in my scientific career, and my goal is to hold an interdisciplinary research environment for cultivating next-generation scientists.

Dr. Cheng is a developmental neurobiologist. New positions are open for Laboratory Assistants and Post-doctoral Fellows who are interested in using mouse and/or C. elegans to study molecular and cellular mechanisms of axon guidance and adult neurogenesis.