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“Sng” or “Sng-pain” is a Taiwanese term that denotes an acid-like discomfort, one of the most common complaints in pain clinics. Although the cost of medical care spent on sng or sng-pain is the highest among all diseases all over the world, current analgesics are not very effective for many types of intractable sng or sng-pain (e.g., fibromyalgia). To solve the unmet medical needs of intractable sng-pain, the research team have found sng and pain are two different somatosensory functions, with proprioceptors are the sngceptors to sense tissue acidosis and to trigger the acid-induced priming and “pain” chronicity in moused models of fibromyalgia.

This study was conducted by Dr. Chih-Cheng Chen, a distinguished research fellow and his research team at Academia Sinica, with supported from the National Science and Technology Council’s Brain Technology Project and the Investigator Award of Academia Sinica. These findings were published in the prestigious international journal Science Advancesin January 31, 2025.