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Current and upcoming facilities like SKA, HERA, LOFAR and JWST will unleash a flood of high redshift (z>5) observational data that will usher the study of the Epoch of Reionization (EoR) into a new era, making it the next big frontier in cosmological structure formation. It is therefore important for theoretical models to achieve sufficient accuracy and physical fidelity to meaningfully interpret these observational results. This requires a realistic description of galaxy formation in an evolving radiation field. In this talk, I will introduce the THESAN simulation project that couples state-of-the-art galaxy formation models (like IllustrisTNG & SMUGGLE) with radiative transfer, dust, and non-equilibrium thermochemistry to comprehensively study high redshift galaxy formation and reionization. The suite consists of both large volume reionization simulations (~100 Mpcs) focused on studying the large-scale properties of the IGM and zoom-in simulations of individual galaxies at unprecedented (~ 10 pc) resolution, designed to investigate the sources responsible for the reionization process. I will present results from this suite and discuss the advantages of using this multi-pronged approach to studying high redshift structure formation.