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Highly integrated analytical platform for streamlined single cell proteomics profiling

Date: 2022-02-23

Single-cell omics analysis is the enabling technology for precision medicine. Compared to genomics and transcriptomics, the development of single-cell proteomics (SCP) tools is substantially lagged behind. To improve the sensitivity and proteome depth of SCP, Drs. Hsiung-Lin Tu’s and Yu-Ju Chen’s team at Institute of Chemistry,Academia Sinica has developed an integrated microfluidics system for streamlined SCP profiling. Coupled with data-independent acquisition mass spectrometry, this platform successfully identified ~1500 proteins from a single cell. The team is working on developing next-generation chip, and hope to implement this strategy to reveal the molecular mechanism of how single cell regulate the physiology and pathology. 

Tag: #Chemistry