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A novel IL-18-mediated anti-bacterial circuit to enforce intestinal host defense and immunity
Date: 2022-02-21
Tissue-protective cytokine IL-22 targets epithelial lineages such as the gastrointestinal system. Clinical relevance of IL-22 to IBD is well-established and IL-22 therapy is promising for IBD treatment as IL-22 is capable of promoting epithelial repair and inducing production of anti-microbial peptides. A work in Nature Communications conducted by Dr. Jr-Wen Shui at Institute of Biomedical Sciences, identify a novel anti-bacterial circuit, showing during E coli infection, IL-22 initiates an IL-18 epithelial response circuit to enforce immunity, which provides therapeutic insights of using IL-22/IL-18 as a potential anti-inflammatory target.
