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Syngeneic Natural Killer Cell Therapy Activates Dendritic and T Cells in Metastatic Lungs and Effectively Treat Low-burden Metastases

Date: 2024-06-28

Natural killer (NK) cells control metastasis, however, the mechanisms are not fully understood. Dr. Nan-Shih Liao's team at the Institute of Molecular Biology established a spontaneous breast cancer metastasis and primary tumor resection mouse model that mimics recurrence in patients after resection. They found that syngeneic NK cell therapy is effective in treating established low-burden metastases depending on CD8+ T cells and induces a tumor-specific protective T cell memory. Furthermore, NK cell transfer augments activation of dendritic cells, Foxp3-CD4+ T cells and stem cell-like CD8+ T cells in metastatic lungs, which requires IFN-γ of the transferred NK cells.

A trial of autologous NK cell therapy in six advanced cancer patients was conducted with Dr. Ming-Shen Dai at Tri-Service General Hospital, which showed safety and signs of effectiveness. This work was published on June 19, 2024 in eLife. The three co-first authors are Shih-Wen Huang from TIGP-MCB Ph.D. program, IMB Postdoc Researcher Dr. Yein-Gei Lai, and Hao-Ting Liao from Master program of Department of Life Sciences, National Central University.

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