Heart failure remains a significant global cause of mortality, characterized by the adult human heart's inability to repair itself or compensate for the loss of cardiac muscle cells. Cell therapy, specifically employing stem cells, has emerged as a promising avenue for restoring lost cardiac muscle cells and reviving heart function. Led by the Distinguished Research Fellow Patrick CH Hsieh at the Institute of Biomedical Sciences, Academia Sinica in Taiwan, a pioneering research team has achieved noteworthy breakthroughs in both murine and non-human primate models. The research successfully restored and regenerated damaged hearts through the co-transplantation of human induced pluripotent stem cell (iPSC)-derived endothelial cells and cardiomyocytes. This groundbreaking study, entitled "Combined Treatment of Human iPSC-derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-human Primates," has been published in the prestigious journal Circulation on October 31, 2023. The collaboration between the research team and esteemed scientists from both Taiwan and the United States, including Dr. Tim Kamp and Dr. Tim Hacker from the University of Wisconsin-Madison, has ushered in a new era of possibilities in the field of cardiac regeneration.