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Abstract

We compared the effects of plasma with thermal therapy on lung cancer with malignant pleural effusion. This study find out that the plasma can selectively kill lung cancer cells and the benign cells remain its viability. Besides, the thermal therapy kills both cancer cell and benign cells. To investigate what is the plasma factor that inhibits cancer cells, we investigated the effects of plasma-generated short-lived species, long-lived species, and electric fields on skin melanoma and basal cell carcinoma cells (A2058 cells, BCC cells) and normal cells (BJ cells, Detroit 551 cells) and found that the short-lived species do make selective inhibition to the benign and malignant cells. The second part of my study is that we mix water aerosol with plasma jet at downstream region makes the plasma jet generate more • OH. We designed different mixing chambers and adjusting the water aerosol flow rate maximize the • OH generated by plasma jet for biological applications. We also constructed an impedance matching circuit for a partial-discharge calibrated (PDC) atmospheric-pressure plane-to-plane DBD equivalent circuit. We also developed a portable microbubble generation device that infuses water with nitric oxide (NO) gas, enhancing its solubility and potential for skin penetration. By optimizing factors such as voltage duty cycles, spark plug configurations, and Venturi pipe design, the system effectively increases NO concentration in microbubble water. The compact and reusable design offers a cost-effective alternative to traditional NO delivery methods while addressing gas leakage concerns.