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Nanomedicine and biomaterials have attracted much attention in recent decades for disease treatments. Notably, these advancements in cardiovascular disease, cancer, and inflammatory disease treatments hold significant promise for addressing unmet medical needs. The first section of the presentation will focus on the utilization of macrophage-modulating nano-biologics for atherosclerotic cardiovascular disease immunotherapy. The second section of the presentation will highlight the biomedical applications of innovative nanomaterials and polymeric nanoparticles in diverse cancer therapies. Finally, the application of engineered living materials for drug delivery in treating intestinal diseases will also be presented.