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Abstract
        Bisphenol A (BPA) is widely utilized as a fundamental component in the manufacture of polycarbonate plastics and epoxy resins around the world. Nonetheless, BPA is also identified as a prominent endocrine-disrupting chemical. Consequently, a variety of BPA derivatives and related substances have been developed and employed as alternatives to BPA. Despite the fact that the safety of these "next-generation bisphenols" has not been thoroughly assessed, their use has risen considerably. In this research, we examined around 200 BPA derivatives for their binding affinity to estrogen receptors (ERα and ERβ) using radiolabelled 17β-estradiol and assessed their transcriptional activity in HeLa cells. We discovered that certain halogen-containing next-generation bisphenols suppressed the transcriptional activity of ERα. Notably, we observed that many next-generation BPAs, such as BPC and BPAF, functioned as antagonists for ER, even though they are agonists for ER. We demonstrated that these next-generation bisphenols act as inhibitors of coactivator binding against ER.

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