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• Paweł Sajkiewicz, PhD, DSc
  Professor, Materials Engineering and Biomedical Engineering, Institute of Fundamental Technological Research of the Polish Academy of Sciences (IPPT PAN)

• Zahra Moazzami Goudarzi
  Specialist & Ph.D. Candidate, Laboratory of Polymers & Biomaterials
  Institute of Fundamental Technological Research, Polish Academy of Sciences (IPPT PAN)

Tissue regeneration remains a major clinical challenge due to limited self-repair capacity, poor vascularization, and the inability of current therapies to meet both mechanical and biological demands. Current scaffolds and drug-delivery systems often lack the controlled, bioactive environment required for effective healing.
Our research introduces a multifunctional biomaterial platform that integrates smart hydrogels and advanced fibrous structures for a wide range of tissue-regeneration applications. The thermoresponsive hydrogel incorporating superparamagnetic iron oxide nanoparticles (SPIONs) enables on-demand, magnetically triggered drug release, creating a supportive matrix for cellular growth and cancer treatment. In parallel, electrospun fibers with tunable mechanical and physicochemical properties provide additional structural reinforcement and can serve as sustained-release carriers for therapeutic agents.
The project focuses on designing and optimizing these complementary systems, evaluating their biocompatibility, mechanical behavior, and controlled drug-release profiles. By combining hydrogel responsiveness with the versatility of electrospun nanofibers, this approach aims to deliver an adaptable and effective strategy for next-generation tissue-regeneration therapies.