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Wood is the most abundant carbon biomass on earth and the major source of sustainable green fibers and bioproducts. Globally, 315 gigatons of carbon are stored as wood, representing 57% of the biogenic carbon sink. Despite the importance of wood products, their production has remained largely limited to undomesticated forest trees with often sub-optimal wood properties that hamper production efficiency. Here, we show that strategic multiplex CRISPR-based genome editing of monolignol biosynthesis genes improves wood properties beyond natural variations or the editing of single genes. By assessing every possible combination of multigenic-editing strategies for 21 lignin biosynthesis genes, we deduced unique genome-editing strategies targeting the concurrent alteration of up to 6 genes. CRISPR-editing increased the wood carbohydrate-to-lignin ratio up to 228% of wildtype, leading to more efficient bioprocessing. The edited wood alleviates a major fiber-production bottleneck and could bring unprecedented operational efficiencies, bioeconomic opportunities, and environmental benefits.