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Memories are crucial for daily life, yet the network-level principles that govern the neural representations of memories remain unclear. Our recent research has shed light on this, providing evidence that the hippocampus and its associated neural networks utilize a many-to-one weighted mapping principle to rapidly encode and store new memories. In our ongoing studies, we explore how the brain accomplishes complex associative learning while preserving memory precision. Our findings suggest that a prefrontal–raphe–hippocampal circuit plays an essential role in governing the top-down regulation of complex associative learning. Specifically, this circuit predominantly drives raphe Vglut3 neurons to coordinate information binding across hippocampal-cortical networks, which likely enhances memory precision. Our research provides new insights into the neural mechanisms underlying the rapid formation of everyday memories and underscores the importance of top-down prefrontal control in maintaining memory precision.