> Post Doctor    吳渝樺    Wu, Yu-Hauh 　 Email: wuyh0816@gate.sinica.edu.tw Telephone: 02-27855696 ext 5010

* EDUCATION AND POSITIONS HELD

1991- B.S., China Medical University 1996- Ph.D., National Taiwan University

* HONORS

2004- Postdoctoral Research Associate , Academia Sinica

* RESEARCH INTERESTS

Structural enzymology: For development of therapeutics for diabetes and related metabolic disorders, enzymes involved in the key step of prostaglandin metabolism are under investigation. Cell death signaling: Apoptotic mechanism triggered by natural toxins such as ricin and abrin. Exploring novel apoptotic regulators with potential for anti-cancer drug exploitation.

* SELECTED PUBLICATIONS

Wu, Y. H., Shih, S. F., and Lin, J. Y. (2004) Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3. J. Biol. Chem. 279 (18), 19264-19275. Shih, S. F., Wu, Y. H., Hung, C. H., Yang, H.Y., and Lin, J. Y. (2001) Abrin triggeres cell death by inactivating a thiol-specific antioxidant protein. J. Biol. Chem. 276 (24), 21870-21877.