> Assistant

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   Shr, Hui-Lin

 
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E-mail: mbce0326@imb.sinica.edu.tw
Telephone: 02-2785-5696 ext.4140

* EDUCATION AND POSITIONS HELD

  • Bachelor of Biology

  • Research assistant

* RESEARCH INTERESTS

  • Specialized in crystallization

  • Protein purification and protein structure

* SELECTED PUBLICATIONS

  1. Sun, Y.-J.*, Forouhar, F.*, Li, H.-M., Tu, S.-L., Kao, S., Shr, H.-L., Yeh, Y.-H., and Hsiao, C.-D. (2002). Crystal structure of pea Toc34 - a novel GTPase of the chloroplast protein translocon. Nat. Struct. Biol. 9 , 95-100. (* these authors contributed equally to this work). [PubMed] [PDB]

  2.  Chou, C.-C., Forouhar, F., Yeh, Y.-H., Shr, H.-L. Wang, C. and Hsiao, C.-D. (2003). Crystal structure of the C-terminal 10 kDa subdomain of Hsc70. J. Biol. Chem. 278 , 30311-30316. [PubMed] [PDB]

  3.  Guo, R.-T., Ko, T.-P., Chou, C.-C., Shr, H.-L., Chu, H.-M., Tsai, Y.-H., Liang, P.-H. and Wang, A. H.-J. (2003 ) Acta. Cryst. D59, 2265 - 2268. ¡§ Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. ¡¨

  4.  Chu HM, Guo RT, Lin TW, Chou CC, Shr HL, Lai HL, Tang TY, Cheng KJ, Selinger BL, Wang AH. (2004 ) Structure (Camb). 2004 Nov; 12(11), 2015 - 2024. ¡§ Structures of Selenomonas ruminantium Phytase in Complex with Persulfated Phytate; DSP Phytase Fold and Mechanism for Sequential Substrate Hydrolysis.

  5.  Chung TL, Hsiao HH, Yeh YY, Shia HL, Chen YL, Liang PH, Wang AH, Khoo KH, Li SS. (2004 ) J Biol Chem. July 22, 1 - 34. ¡§ In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: Definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. ¡¨

  6.  Guo, R.-T., Ko, T.-P., Chou, C.-C., Shr, H.-L., Chu, H.-M., Tsai, Y.-H., Liang, P.-H. and Wang, A. H.-J. (2003 ) Acta. Cryst. D59, 2265 - 2268. ¡§ Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. ¡¨

  7.  Guo RT, Ko TP, Chou CC, Shr HL, Chu HM, Tsai YH, Liang PH, Wang AH. (2003 ) Acta Crystallogr D Biol Crystallogr. 59(Pt 12), 2265 - 2268. ¡§ Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. ¡¨

  8.  Guo, R.-T., Kuo, C.-J., Chou, C.-C., Ko, T.-P., Shr, H.-L., Liang, P.-H. and Wang, A. H.-J. (2004 ) J. Biol. Chem. 279, 4903 - 4912. ¡§ Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic thermotoga and mechanism of product chain length determination. ¡¨

  9.  Hsu MF, Kuo CJ, Fang JM, Shie JJ, Chang KT, Chang HC, Chou CC, Ko TP, Shr HL, Chang GG, Wu YT, -J Wang AH, Liang PH. (2005). J Biol Chem. Jun 21. ¡§ Understanding the maturation process and inhibitor design of SARS-CoV 3CLpro from the crystal structure of C145A in a product-bound form. ¡¨

  10.  K.-H. Chin, Z.-W. Huang, K.-C. Wei, C.-C. Chou, C.-C. Lee, H.-L. Shr, F. P. Gao, P.-C. Lyu, A.H.-J. Wang and S.-H. Chou. (2005). Acta Cryst. F61, 691-693. ¡§ Preparation, crystallization and preliminary X-ray characterization of a conserved hypothetical protein XC1692 from Xanthomonas campestris. ¡¨

  11.  K.-H. Chin, W.-T. Kuo, C.-C. Chou, H.-L. Shr, P.-C. Lyu, A.H.-J. Wang and S.-H. Chou. (2005).Acta Cryst. F61, 694-696 . ¡§ Cloning, purification, crystallization and preliminary X-ray analysis of XC229, a conserved hypothetical protein from Xanthomonas campestris. ¡¨

  12. C.-L. Chu, K.-H. Chin, F.-Y. Lin, C.-C. Chou, C.-C. Lee, H.-L. Shr, P.-C. Lyu, A.H.-J. Wang and S.-H. Chou. (2005) . Acta Cryst. F61, 697-699 . ¡§A putative polyketide-synthesis protein XC5357 from Xanthomonas campestris: heterologous expression, crystallization and preliminary X-ray analysis. ¡¨

  13. K.-H. Chin, C.-C. Chou, C.-C. Lee, H.-L. Shr, P.-C. Lyu, A.H.-J. Wang and S.-H. Chou. (2005) . Acta CrystF61, 700-702. ¡§Preparation, crystallization and preliminary X-ray analysis of XC2382, an ApaG protein of unknown structure from Xanthomonas campestris. ¡¨

  14. C.-Y. Yang, K.-H. Chin, C.-C. Chou, H.-L. Shr, F. P. Gao, P.-C. Lyu, A.H.-J. Wang and S.-H. Chou. (2005). Acta Cryst. F61, 703-705 . ¡§Cloning, purification crystallization and preliminary X-ray characterization of a conserved hypothetical protein XC6422 from Xanthomonas campestris. ¡¨

  15. Z.-L. Tu, J.-N. Li, K.-H. Chin, C.-C. Chou, C.-C. Lee, H.-L. Shr, P.-C. Lyu, F. P. Gao, A.H.-J. Wang and S.-H. Chou. (2005). Acta Cryst. F61, 706-708 . ¡§ Cloning, expression, crystallization and preliminary X-ray analysis of a putative multiple antibiotic resistance repressor protein (MarR) from Xanthomonas campestris. ¡¨
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