> Principal Investigator
¡@

   ¤ý´f¶v
   Andrew H.-J. Wang
¡@



Email: ahjwang@gate.sinica.edu.tw
Telephone: 02-27855696 ext 5010

* Education and Positions Held
Present Distinguished Research Fellow and Director, Institute of Biological Chemistry, Academia Sinica
1974 - Ph.D., University of Illinois at Urbana-Champaign.
1970 - M.S. , National Taiwan University.
1967 - B.S., National Taiwan University.

* Positions
2006- Vice President, Academia Sinica
Distinguished Research Fellow, Institute of Biological Chemistry
2000-2006 Distinguished Research Fellow and Director, Institute of Biological Chemistry, Academia Sinica
1996-1997 Acting Head, Dept. of Cell & Structural Biology, UIUC
1988-2000 Professor of Biophysics, Biochemistry, and Chemistry, Dept. of Cell & Structural Biology, Biochemistry, UIUC
2/95-5/95 Visiting Professor, Department of Biophysical Chem., Nijmegen University
(with Prof. C. Hilbers)
9/87-2/88 Visiting Associate, Division of Chemistry, Caltech (with Prof. P. B. Dervan)
1-7/81 &
3-4/83		 Visiting Scientist, Gorlaeus Lab., Leiden State Univ., The Netherlands (with Prof. J. H. van Boom)
1974-88 Postdoctoral Research Associate (74-80), Research Scientist (80-82),
Principal Research Scientist (82-85), Senior Research Scientist (85-88),
Department of Biology, MIT

* Other Professional Activities
2003-present Council Member, AOHUPO
2003-present Council Member, Human Proteomic Organization (HUPO)
2003-2006 President, Taiwan Proteomics Society
2001-2004 President, Taiwan Society of Biochemistry and Molecular Biology
2001-present President, Biophysics Society of ROC
2002-present Adj. Distinguished Research Fellow, Institute of Mol. Biol., Taipei, Taiwan
1998-2002 Editorial Board, Nucleic Acids Research
1995-2002 Editor, European J. Biochem.
1993-1996 Member, NSF Predoctoral Fellowship Review Panel
1992-2002 Adj. Research Fellow, Institute of Mol. Biol., Taipei, Taiwan
1991-1994 Member, NIH BBCA Study Section
1990-1993 Member, Advisory Board, Biotechnology Center, UIUC
1988-1996 Member, Advisory Board, Institute of Mol. Biol., Taipei, Taiwan
1987-present Member, Oversea Advisory Board, Newton Graphic Science Magazine (Taiwan)
1984-1994 Member, Organizing Committee for the SUNYA Conversation in the Discipline of Biomolecular Stereodynamics
1984 Director, Second Summer School in Biophysics, International Center for Theoretical Physics, Trieste, Italy
1983-1994 Member, Editorial Board, J. Biomol. Struct. Dyn.

* Membership
2005 Fellow, The Third World Academy of Sciences (TWAS)
2000 Academician, Academia Sinica
1998 Fellow, American Association for the Advancement of Science
1987 Fellow, American Institute of Chemists
1987 Elected member, American Society for Biochemistry & Molecular Biology

* Research Interests

Structural proteomics, anticancer drugs, x-ray crystallography, NMR and molecular design.

Structural enzymology: Several enzymes as potential targets for drug discovery are under investigation. For developing new antibiotics, we focus on prenyltransferases and glyco-related enzymes. For anti-viral and anticancer agents, we analyze proteases (3CL proteases, MMPs), and phosphatases (DuSPs in signal transduction). Studies of potential targets for diabetics and Alzeheimer's disease are also in progress.

Protein- & anticancer drug-DNA interactions: Some DNA-binding proteins (like chromosomal proteins and proteins involved in meiosis) and many important anticancer drugs with DNA are of interest. The results can be useful for the design of new anticancer agents.

 Search for disease markers: Proteomic approaches, including 2D-GE and nanoLC, mass spectrometry and bioinformatics, are used to analyze cells and tissues from certain diseases to identify potential marker proteins. We are particularly interested in serum samples.

 Proteins from extreme environments: Microorganisms that live in extreme environments including extreme heat, cold, pH (acidic or alkaline) or radiation resistance have unusual proteins. Some enzymes described above are from those organisms.