> Introduction

1. Structural enzymology:
Several enzymes as potential targets for drug discovery are under investigation. For developing new antibiotics, we focus on prenyltransferases and glyco-related enzymes. For anti-viral and anticancer agents, we analyze proteases (3CL proteases, MMPs), and phosphatases (DuSPs in signal transduction). Studies of potential targets for diabetics and Alzeheimer's disease are also in progress.

2. Protein- & anticancer drug-DNA interactions:
Some DNA-binding proteins (like chromosomal proteins and
      proteins involved in meiosis) and many important anticancer
      drugs with DNA are of interest. The results can be useful for
      the design of new anticancer agents.

 3. Search for disease markers:
    Proteomic approaches, including 2D-GE and nanoLC, mass
    spectrometry and bioinformatics, are used to analyze cells
        and tissues from certain diseases to identify potential
        marker proteins. We are particularly interested in
        serum samples.

         4. Proteins from extreme environments:
                   Microorganisms that live in extreme environments
                   including extreme heat, cold, pH (acidic or alkaline)
                   or radiation resistance have unusual proteins.
                   Some enzymes described above are from those
                   organisms.