> Ph.D. Student

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   Guo, Rey-Ting

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E-mail: reyting@gate.sinica.edu.tw
Telephone: 02-2785-5696 ext.5010

* EDUCATION AND POSITIONS HELD

  • Bachelor of Science, Department of Chemistry, Chemistry, Tamkang University, Taiwan, 1995

  • Mater of Science, Department of Biochemistry, National Cheng Kung University, Taiwan, 1998

  • Ph. D. student, Taiwan International Graduate Program, CBMB, Academia Sinica, Taiwan, present

* HONORS

  • The Ninth Symposium on Recent Advances in Biophysics, 2004 (The Third Place of Poster Competition)

* RESEARCH INTERESTS

  • Structural and functional studies of Octaprenyl pyrophosphate synthase (OPPs) from Thermotoga maritima.

  • Structural and functional studies of Undecaprenyl pyrophosphate synthase (UPPs) from Escherichia coli.

  • Structural and functional studies of membrane protein.

* SELECTED PUBLICATIONS

  • Guo, R. T*., Ko, T. P*., Chen, A. P.-C., Kuo, C. J., Wang, A. H.-J**., Liang, P. H**. (2005) Crystal Structures of Undecaprenyl Pyrophosphate Synthase in Complex with Magnesium, Isopentenyl Pyrophosphate, and Farnesyl Thiopyrophosphate. J. Biol. Chem. 280, 20762-20774.

  • Guo, R. T*., Kuo, C. J*., Ko, T. P., Chou, C. C., Liang, P. H**., and Wang, A. H.-J**. (2004) A Molecular Ruler for Chain Elongation Catalyzed by Octaprenyl Pyrophosphate Synthase and Its Structure-Based Engineering to Produce Unprecedented Long-Chain Trans-Prenyl Products. Biochemistry. 43, 7678-7686.

  • Guo, R. T., Kuo, C. J., Chou, C. C., Ko, T. P., Shr, H. L., Liang, P. H**., and Wang, A. H.-J**. (2004) Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination. J. Biol. Chem. 279, 4903-4912.

  • Guo, R. T., Ko, T. P., Chou, C. C., Shr, H. L., Chu, H. M., Tsai, Y. H., Liang, P. H., and Wang, A. H.-J. (2003) Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. Acta Crystallogr. Sect. D Biol. Crystallogr. 59, 2265-2268.

  • Guo, R. T., Chou, L. J., Chen, Y. C., Chen, C. Y., Pari, K, Jen, C. Y., Lo, S. C., Huang, S. L., Lee, C. Y., Chang, T. W., Chuang, W. J. (2001) Expression in Pichia pastoris and Characterization by Circular and NMR of Rhodostomin. Proteins: Structure, Function, and Genetics. 43, 499-508.